Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

Wing Kei Chan; Chi Ming Ho; Man Kin Wong; Chi Ming Che

doi:10.1021/ja064479s

Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

Wing Kei Chan
, Chi Ming Ho
, Man Kin Wong
, Chi Ming Che

Research output: Journal article publication › Journal article › Academic research › peer-review

175 Citations (Scopus)

Abstract

A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.

Original language	English
Pages (from-to)	14796-14797
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	46
DOIs	https://doi.org/10.1021/ja064479s
Publication status	Published - 22 Nov 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja064479s

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abstract = "A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96\%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.",

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AU - Che, Chi Ming

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AB - A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.

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DO - 10.1021/ja064479s

M3 - Journal article

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

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Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

Abstract

ASJC Scopus subject areas

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