Oxidative amide synthesis and N-terminal α-amino group ligation of peptides in aqueous medium

Wing Kei Chan, Chi Ming Ho, Man Kin Wong, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

143 Citations (Scopus)

Abstract

A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal α-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.
Original languageEnglish
Pages (from-to)14796-14797
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number46
DOIs
Publication statusPublished - 22 Nov 2006
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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