TY - JOUR
T1 - Overweight in children is associated with arterial endothelial dysfunction and intima-media thickening
AU - Woo, K. S.
AU - Chook, P.
AU - Yu, C. W.
AU - Sung, R. Y.T.
AU - Qiao, M.
AU - Leung, S. S.F.
AU - Lam, C. W.K.
AU - Metreweli, C.
AU - Celermajer, D. S.
N1 - Funding Information:
We wish to acknowledge the contributions of Ms Alice SP Cheung, Lindy LT Chan and Amy SL Lam of the Department of Medicine & Therapeutics of the Prince of Wales Hospital to this work. This project was supported by the Hong Kong Institute of Heart Health Promotion, the Shaw Foundation and the Research Grant Council of Hong Kong (CUHK4060/ 2000 M).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/7
Y1 - 2004/7
N2 - OBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
AB - OBJECTIVE: We sought to study arterial endothelial function and carotid intima-media thickness (IMT), both early markers of atherosclerosis, in overweight compared to normal children. DESIGN: Case-control comparison. SUBJECTS: A total of 36 asymptomatic overweight children (body mass index (BMI) > 23; mean 25 ± 3) aged 9-12 y and 36 age- and gender-matched nonobese healthy children (BMI < 21) from a school community. MEASUREMENTS: The key parameters were: BMI, arterial endothelial function (ultrasound-derived endothelium-dependent dilation) and carotid artery IMT. The secondary parameters measured included body fat content, waist-hip ratio (WHR), blood pressures, blood lipids, insulin and glucose. RESULTS: The two groups were well matched for blood pressures, cholesterol and glucose levels, but BMI (P<0.0001), body fat (P = 0.001), WHR (P < 0.05), fasting blood insulin (P = 0.001) and triglyceride levels (P < 0.05) were higher in obese children. Overweight was associated with impaired arterial endothelial function (6.6 ± 2.3 vs 9.7 ± 3.0%, P < 0.0001) and increased carotid IMT (0.49 ± 0.04 mm vs 0.45 ± 0.04 mm, P = 0.006). The degree of endothelial dysfunction correlated with BMI (P < 0.003) on multivariate analysis. CONCLUSION: Obesity, even of mild-to-moderate degree, is independently associated with abnormal arterial function and structure in otherwise healthy young children.
KW - Atherosclerosis
KW - Body mass index
KW - Carotid intima-media thickening
KW - Endothelium
KW - Overweight in children
UR - http://www.scopus.com/inward/record.url?scp=3442880238&partnerID=8YFLogxK
U2 - 10.1038/sj.ijo.0802539
DO - 10.1038/sj.ijo.0802539
M3 - Journal article
C2 - 15170465
AN - SCOPUS:3442880238
SN - 0307-0565
VL - 28
SP - 852
EP - 857
JO - International Journal of Obesity
JF - International Journal of Obesity
IS - 7
ER -
