Organic Photo-Electrochemical Transistor-Based Biosensor: A Proof-of-Concept Study toward Highly Sensitive DNA Detection

Jiajun Song, Peng Lin, Yi Fan Ruan, Wei Wei Zhao, Weiwei Wei, Jin Hu, Shanming Ke, Xierong Zeng, Jing Juan Xu, Hong Yuan Chen, Wei Ren, Feng Yan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

25 Citations (Scopus)


Organic bioelectronics have shown promising applications for various sensing purposes due to their significant advantages in term of high flexibility, portability, easy fabrication, and biocompatibility. Here, a new type of organic device, organic photo-electrochemical transistor (OPECT), is reported, which is the combination of an organic electrochemical transistor and a photo-electrochemical gate electrode modified with CdS quantum dots (QDs). Thanks to the inherent amplification function of the transistor, the OPECT-based biosensor exhibits much higher sensitivity than that of a traditional biosensor. The sensing mechanism of the OPECT is attributed to the charge transfer between the photosensitive semiconductor CdS QDs and the gate electrode. In an OPECT-based DNA sensor, target DNA is labeled with Au nanoparticles (NPs) and captured on the gate electrode, which can influence the charge transfer on the gate caused by the exciton–plasmon interactions between CdS QDs and Au NPs. Consequently, a highly sensitive and selective DNA sensor with a detection limit of around 1 × 10−15 m is realized. It is expected that OPECTs can be developed as a high-performance platform for numerous biological detections in the future.

Original languageEnglish
Article number1800536
JournalAdvanced healthcare materials
Issue number19
Publication statusPublished - 10 Oct 2018


  • DNA sensors
  • exciton–plasmon interaction
  • organic electrochemical transistors
  • organic photo-electrochemical transistors
  • photo-electrochemical sensors

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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