Organic-Dye-Modified Upconversion Nanoparticle as a Multichannel Probe to Detect Cu2+ in Living Cells

Bin Gu, Minan Ye, Lina Nie, Yuan Fang, Zilong Wang, Xiao Zhang, Hua Zhang, Yi Zhou, Qichun Zhang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

42 Citations (Scopus)

Abstract

The development of an inorganic-organic hybrid probe to more accurately detect ions in living systems is very challenging but highly desirable. Here we combined upconversion nanoparticles with the electrically active ferrocene group to detect Cu2+ in living cells. The as-prepared probe displays three different signal changes in absorption, emission, and electrochemical behavior, respectively, during Cu2+ ion detection. Moreover, this new probe has been demonstrated to show high stability and adaptability. In addition, bioimaging testing reveals that this probe is suitable for detecting and visualizing Cu2+ in A549 cells with low cytotoxicity.

Original languageEnglish
Pages (from-to)1028-1032
Number of pages5
JournalACS Applied Materials and Interfaces
Volume10
Issue number1
DOIs
Publication statusPublished - 10 Jan 2018
Externally publishedYes

Keywords

  • bioimaging
  • electrochemistry
  • emission
  • multichannel
  • upconversion

ASJC Scopus subject areas

  • Materials Science(all)

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