Optofluidic bioanalysis: Fundamentals and applications

Damla Ozcelik, Hong Cai, Kaelyn D. Leake, Aaron R. Hawkins, Holger Schmidt

Research output: Journal article publicationReview articleAcademic researchpeer-review

31 Citations (Scopus)

Abstract

Over the past decade, optofluidics has established itself as a new and dynamic research field for exciting developments at the interface of photonics, microfluidics, and the life sciences. The strong desire for developing miniaturized bioanalytic devices and instruments, in particular, has led to novel and powerful approaches to integrating optical elements and biological fluids on the same chip-scale system. Here, we review the state-of-the-art in optofluidic research with emphasis on applications in bioanalysis and a focus on waveguide-based approaches that represent the most advanced level of integration between optics and fluidics. We discuss recent work in photonically reconfigurable devices and various application areas. We show how optofluidic approaches have been pushing the performance limits in bioanalysis, e.g. in terms of sensitivity and portability, satisfying many of the key requirements for point-of-care devices. This illustrates how the requirements for bianalysis instruments are increasingly being met by the symbiotic integration of novel photonic capabilities in a miniaturized system.

Original languageEnglish
Pages (from-to)647-661
Number of pages15
JournalNanophotonics
Volume6
Issue number4
DOIs
Publication statusPublished - Mar 2017
Externally publishedYes

Keywords

  • Biosensing
  • integrated optics
  • lab-on-chip
  • optofluidics
  • photonics

ASJC Scopus subject areas

  • Biotechnology
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

Fingerprint

Dive into the research topics of 'Optofluidic bioanalysis: Fundamentals and applications'. Together they form a unique fingerprint.

Cite this