Optimization of Biosensing Microcantilever Devices

Xuan Zhang; Mo Yang; Cengiz S. Ozkan

Optimization of Biosensing Microcantilever Devices

Xuan Zhang, Mo Yang, Cengiz S. Ozkan

Research output: Journal article publication › Conference article › Academic research › peer-review

Abstract

Optimization of piezoresistive microcantilevers for biosensing applications has been studied using finite element analysis. Models have been described for predicting the static behavior of cantilevers with elastic and piezoresistive layers for analyte-receptor binding. The high-sensitivity cantilevers can be used to detect changes in surface stress due to the binding and hybridization of biomolecules. Chemo-mechanical binding forces have been analyzed to understand the issues of saturation over the cantilever surface. The introduction of stress concentration regions during cantilever fabrication has also been discussed which enhances the detection sensitivity through increased surface stress.

Original language	English
Pages (from-to)	135-141
Number of pages	7
Journal	Materials Research Society Symposium - Proceedings
Volume	773
Publication status	Published - 1 Dec 2003
Externally published	Yes
Event	Biomicroelectromechanical Systems (BioMEMS) - San Francisco, CA, United States Duration: 22 Apr 2003 → 25 Apr 2003

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Cite this

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title = "Optimization of Biosensing Microcantilever Devices",

abstract = "Optimization of piezoresistive microcantilevers for biosensing applications has been studied using finite element analysis. Models have been described for predicting the static behavior of cantilevers with elastic and piezoresistive layers for analyte-receptor binding. The high-sensitivity cantilevers can be used to detect changes in surface stress due to the binding and hybridization of biomolecules. Chemo-mechanical binding forces have been analyzed to understand the issues of saturation over the cantilever surface. The introduction of stress concentration regions during cantilever fabrication has also been discussed which enhances the detection sensitivity through increased surface stress.",

author = "Xuan Zhang and Mo Yang and Ozkan, {Cengiz S.}",

year = "2003",

month = dec,

day = "1",

language = "English",

volume = "773",

pages = "135--141",

journal = "Materials Research Society Symposium - Proceedings",

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publisher = "Materials Research Society",

note = "Biomicroelectromechanical Systems (BioMEMS) ; Conference date: 22-04-2003 Through 25-04-2003",

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T1 - Optimization of Biosensing Microcantilever Devices

AU - Zhang, Xuan

AU - Yang, Mo

AU - Ozkan, Cengiz S.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Optimization of piezoresistive microcantilevers for biosensing applications has been studied using finite element analysis. Models have been described for predicting the static behavior of cantilevers with elastic and piezoresistive layers for analyte-receptor binding. The high-sensitivity cantilevers can be used to detect changes in surface stress due to the binding and hybridization of biomolecules. Chemo-mechanical binding forces have been analyzed to understand the issues of saturation over the cantilever surface. The introduction of stress concentration regions during cantilever fabrication has also been discussed which enhances the detection sensitivity through increased surface stress.

AB - Optimization of piezoresistive microcantilevers for biosensing applications has been studied using finite element analysis. Models have been described for predicting the static behavior of cantilevers with elastic and piezoresistive layers for analyte-receptor binding. The high-sensitivity cantilevers can be used to detect changes in surface stress due to the binding and hybridization of biomolecules. Chemo-mechanical binding forces have been analyzed to understand the issues of saturation over the cantilever surface. The introduction of stress concentration regions during cantilever fabrication has also been discussed which enhances the detection sensitivity through increased surface stress.

UR - http://www.scopus.com/inward/record.url?scp=1542334495&partnerID=8YFLogxK

M3 - Conference article

SN - 0272-9172

VL - 773

SP - 135

EP - 141

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

T2 - Biomicroelectromechanical Systems (BioMEMS)

Y2 - 22 April 2003 through 25 April 2003

ER -

Optimization of Biosensing Microcantilever Devices

Abstract

ASJC Scopus subject areas

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