Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

W. Z. Song; X. M. Zhang; L. K. Chin; C. S. Lim; A. Q. Liu; P. H. Yap; H. M. Hosseini

Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

W. Z. Song
, X. M. Zhang
, L. K. Chin
, C. S. Lim
, A. Q. Liu
, P. H. Yap
, H. M. Hosseini

Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review

2 Citations (Scopus)

Abstract

This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.

Original language	English
Pages	528-530
Number of pages	3
Publication status	Published - Nov 2006
Externally published	Yes
Event	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 5 Nov 2006 → 9 Nov 2006

Conference

Conference	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country/Territory	Japan
City	Tokyo
Period	5/11/06 → 9/11/06

Keywords

Fabry-Perot cavity
Living cells
Optofluidic microchip
Refractive index

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

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title = "Optical detection of living cells' refractive index via buffer modulation of microfluidic chip",

abstract = "This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.",

keywords = "Fabry-Perot cavity, Living cells, Optofluidic microchip, Refractive index",

author = "Song, \{W. Z.\} and Zhang, \{X. M.\} and Chin, \{L. K.\} and Lim, \{C. S.\} and Liu, \{A. Q.\} and Yap, \{P. H.\} and Hosseini, \{H. M.\}",

year = "2006",

month = nov,

language = "English",

pages = "528--530",

note = "10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 ; Conference date: 05-11-2006 Through 09-11-2006",

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Optical detection of living cells' refractive index via buffer modulation of microfluidic chip. / Song, W. Z.; Zhang, X. M.; Chin, L. K. et al.
2006. 528-530 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review

TY - CONF

T1 - Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

AU - Song, W. Z.

AU - Zhang, X. M.

AU - Chin, L. K.

AU - Lim, C. S.

AU - Liu, A. Q.

AU - Yap, P. H.

AU - Hosseini, H. M.

PY - 2006/11

Y1 - 2006/11

N2 - This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.

AB - This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.

KW - Fabry-Perot cavity

KW - Living cells

KW - Optofluidic microchip

KW - Refractive index

UR - https://www.scopus.com/pages/publications/50049091160

M3 - Conference presentation (not published in journal/proceeding/book)

AN - SCOPUS:50049091160

SP - 528

EP - 530

T2 - 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

Y2 - 5 November 2006 through 9 November 2006

ER -

Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

Abstract

Conference

Keywords

ASJC Scopus subject areas

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