Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

W. Z. Song; X. M. Zhang; L. K. Chin; C. S. Lim; A. Q. Liu; P. H. Yap; H. M. Hosseini

Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

W. Z. Song, X. M. Zhang, L. K. Chin, C. S. Lim, A. Q. Liu, P. H. Yap, H. M. Hosseini

Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review

2 Citations (Scopus)

Abstract

This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.

Original language	English
Pages	528-530
Number of pages	3
Publication status	Published - Nov 2006
Externally published	Yes
Event	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan Duration: 5 Nov 2006 → 9 Nov 2006

Conference

Conference	10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
Country/Territory	Japan
City	Tokyo
Period	5/11/06 → 9/11/06

Keywords

Fabry-Perot cavity
Living cells
Optofluidic microchip
Refractive index

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

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title = "Optical detection of living cells' refractive index via buffer modulation of microfluidic chip",

abstract = "This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.",

keywords = "Fabry-Perot cavity, Living cells, Optofluidic microchip, Refractive index",

author = "Song, {W. Z.} and Zhang, {X. M.} and Chin, {L. K.} and Lim, {C. S.} and Liu, {A. Q.} and Yap, {P. H.} and Hosseini, {H. M.}",

year = "2006",

month = nov,

language = "English",

pages = "528--530",

note = "10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 ; Conference date: 05-11-2006 Through 09-11-2006",

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Optical detection of living cells' refractive index via buffer modulation of microfluidic chip. / Song, W. Z.; Zhang, X. M.; Chin, L. K. et al.
2006. 528-530 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Unpublished conference presentation (presented paper, abstract, poster) › Conference presentation (not published in journal/proceeding/book) › Academic research › peer-review

TY - CONF

T1 - Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

AU - Song, W. Z.

AU - Zhang, X. M.

AU - Chin, L. K.

AU - Lim, C. S.

AU - Liu, A. Q.

AU - Yap, P. H.

AU - Hosseini, H. M.

PY - 2006/11

Y1 - 2006/11

N2 - This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.

AB - This paper reports the measurement of single living cells' refractive index (RI) using a Fabry-Perot (FP) cavity with buffer modulation of microfluidic chip. In the experiment, a single cell is captured in the cavity, and then the spectral shift in response to the buffer change with the presence/absence of cell can be used to determine the cell's RI and size. The microfluidic chip facilitates automatic detection and makes it promising for label-free drug screening.

KW - Fabry-Perot cavity

KW - Living cells

KW - Optofluidic microchip

KW - Refractive index

UR - http://www.scopus.com/inward/record.url?scp=50049091160&partnerID=8YFLogxK

M3 - Conference presentation (not published in journal/proceeding/book)

AN - SCOPUS:50049091160

SP - 528

EP - 530

T2 - 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006

Y2 - 5 November 2006 through 9 November 2006

ER -

Optical detection of living cells' refractive index via buffer modulation of microfluidic chip

Abstract

Conference

Keywords

ASJC Scopus subject areas

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