Open-air oxidative Mizoroki-Heck reaction of arylsulfonyl hydrazides with alkenes

On Ying Yuen, Chau Ming So, Fuk Yee Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

13 Citations (Scopus)

Abstract

A palladium(ii)-catalyzed oxidative Mizoroki-Heck reaction of arylsulfonyl hydrazides with alkenes was developed employing atmospheric air as the sole oxidant in an open-vessel manner. By using palladium(ii) acetate associating with inexpensive, air-stable and moisture stable pyridine ligand L9 as the catalyst system, the efficiency of the reaction could be significantly enhanced. A wide range of arylsulfonyl hydrazides underwent the oxidative Mizoroki-Heck reaction with alkenes smoothly. Good-to-excellent product yields and excellent regio- and stereoselectivity were achieved. Functional groups such as halo, ester etc. were well-tolerated under these optimized reaction conditions.
Original languageEnglish
Pages (from-to)27584-27589
Number of pages6
JournalRSC Advances
Volume6
Issue number33
DOIs
Publication statusPublished - 1 Jan 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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