One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

Jacky C.H. Chu; Chihao Shao; Summer Y.Y. Ha; Wing Ping Fong; Clarence T.T. Wong; Dennis K.P. Ng

doi:10.1039/d1bm01306h

One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

Jacky C.H. Chu, Chihao Shao, Summer Y.Y. Ha, Wing Ping Fong, Clarence T.T. Wong, Dennis K.P. Ng

Research output: Journal article publication › Journal article › Academic research › peer-review

10 Citations (Scopus)

Abstract

We report herein a one-pot approach to cyclise a tumour-Targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications. This journal is

Original language	English
Pages (from-to)	7832-7837
Number of pages	6
Journal	Biomaterials Science
Volume	9
Issue number	23
DOIs	https://doi.org/10.1039/d1bm01306h
Publication status	Published - 7 Dec 2021

ASJC Scopus subject areas

Biomedical Engineering
General Materials Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d1bm01306h

http://hdl.handle.net/10397/95460

Cite this

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title = "One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy",

abstract = "We report herein a one-pot approach to cyclise a tumour-Targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications. This journal is ",

author = "Chu, {Jacky C.H.} and Chihao Shao and Ha, {Summer Y.Y.} and Fong, {Wing Ping} and Wong, {Clarence T.T.} and Ng, {Dennis K.P.}",

note = "Funding Information: This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Ref. No. 14303320). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Chu, Jacky C.H.

AU - Shao, Chihao

AU - Ha, Summer Y.Y.

AU - Fong, Wing Ping

AU - Wong, Clarence T.T.

AU - Ng, Dennis K.P.

N1 - Funding Information: This work was supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Ref. No. 14303320). Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/12/7

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N2 - We report herein a one-pot approach to cyclise a tumour-Targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications. This journal is

AB - We report herein a one-pot approach to cyclise a tumour-Targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications. This journal is

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One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

Abstract

ASJC Scopus subject areas

UN SDGs

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