One-pot peptide cyclisation and surface modification of photosensitiser-loaded red blood cells for targeted photodynamic therapy

Jacky C.H. Chu, Chihao Shao, Summer Y.Y. Ha, Wing Ping Fong, Clarence T.T. Wong, Dennis K.P. Ng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

We report herein a one-pot approach to cyclise a tumour-Targeting peptide and conjugate it on the surface of red blood cells loaded with a boron dipyrromethene-based photosensitiser using a bifunctional linker consisting of a bis(bromomethyl)phenyl unit and an ortho-phthalaldehyde unit. This cell-based photosensitiser with surface modification with cyclic RGD peptide moieties can selectively bind against the αvβ3 integrin-overexpressed cancer cells, leading to enhanced photocytotoxicity. The results demonstrate that this facile strategy is effective for live-cell surface modification for a wide range of applications. This journal is

Original languageEnglish
Pages (from-to)7832-7837
Number of pages6
JournalBiomaterials Science
Volume9
Issue number23
DOIs
Publication statusPublished - 7 Dec 2021

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Science(all)

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