Oncology patients' experiences in experimental medicine cancer trials: a qualitative study

Chelsea Sawyer; Laurie Preston; Sally Taylor; Michelle Davies; Louise Carter; Matthew Krebs; Natalie Cook; Donna Graham; Fiona Thistlewaite; Janelle Yorke

doi:10.1136/bmjopen-2020-047813

Oncology patients' experiences in experimental medicine cancer trials: a qualitative study

Chelsea Sawyer, Laurie Preston, Sally Taylor, Michelle Davies, Louise Carter, Matthew Krebs, Natalie Cook, Donna Graham, Fiona Thistlewaite, Janelle Yorke

Research output: Journal article publication › Journal article › Academic research › peer-review

7 Citations (Scopus)

Abstract

Objectives The study aimed to explore patients' experiences of experimental cancer medicine (ECM) clinical trials. Design The study's design was qualitative. Two focus groups with patients were undertaken followed by semistructured interviews, to explore patients' experiences of ECM clinical trials. Interviews and focus groups were audiorecorded and transcribed verbatim. Data were analysed using thematic analysis. Setting A regional cancer centre (tertiary care) in North-West England. Participants Twelve patients (aged 52-79) participated in one of the two focus groups and 22 patients (aged 42-83) participated in interviews. Primary outcome measure Patients' experiences of an ECM trial. Results Four main themes were identified from the analysis: decision making, information needs, the experience of trial participation and impact of trial participation. Subthemes are presented in the manuscript. Conclusion To make fully informed decisions about trial participation, patients required the simplification of trial information and wanted more information about side effects, their response to trial treatment and the overall trial progress throughout the trial. Patients highlighted the need for improvement for the support provided to their family and friends.

Original language	English
Article number	047813
Journal	BMJ Open
Volume	11
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2020-047813
Publication status	Published - 5 Oct 2021
Externally published	Yes

Keywords

adult oncology
clinical trials
qualitative research

ASJC Scopus subject areas

General Medicine

More information

10.1136/bmjopen-2020-047813

Cite this

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title = "Oncology patients' experiences in experimental medicine cancer trials: a qualitative study",

abstract = "Objectives The study aimed to explore patients' experiences of experimental cancer medicine (ECM) clinical trials. Design The study's design was qualitative. Two focus groups with patients were undertaken followed by semistructured interviews, to explore patients' experiences of ECM clinical trials. Interviews and focus groups were audiorecorded and transcribed verbatim. Data were analysed using thematic analysis. Setting A regional cancer centre (tertiary care) in North-West England. Participants Twelve patients (aged 52-79) participated in one of the two focus groups and 22 patients (aged 42-83) participated in interviews. Primary outcome measure Patients' experiences of an ECM trial. Results Four main themes were identified from the analysis: decision making, information needs, the experience of trial participation and impact of trial participation. Subthemes are presented in the manuscript. Conclusion To make fully informed decisions about trial participation, patients required the simplification of trial information and wanted more information about side effects, their response to trial treatment and the overall trial progress throughout the trial. Patients highlighted the need for improvement for the support provided to their family and friends.",

keywords = "adult oncology, clinical trials, qualitative research",

author = "Chelsea Sawyer and Laurie Preston and Sally Taylor and Michelle Davies and Louise Carter and Matthew Krebs and Natalie Cook and Donna Graham and Fiona Thistlewaite and Janelle Yorke",

note = "Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2021",

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doi = "10.1136/bmjopen-2020-047813",

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AU - Sawyer, Chelsea

AU - Preston, Laurie

AU - Taylor, Sally

AU - Davies, Michelle

AU - Carter, Louise

AU - Krebs, Matthew

AU - Cook, Natalie

AU - Graham, Donna

AU - Thistlewaite, Fiona

AU - Yorke, Janelle

PY - 2021/10/5

Y1 - 2021/10/5

N2 - Objectives The study aimed to explore patients' experiences of experimental cancer medicine (ECM) clinical trials. Design The study's design was qualitative. Two focus groups with patients were undertaken followed by semistructured interviews, to explore patients' experiences of ECM clinical trials. Interviews and focus groups were audiorecorded and transcribed verbatim. Data were analysed using thematic analysis. Setting A regional cancer centre (tertiary care) in North-West England. Participants Twelve patients (aged 52-79) participated in one of the two focus groups and 22 patients (aged 42-83) participated in interviews. Primary outcome measure Patients' experiences of an ECM trial. Results Four main themes were identified from the analysis: decision making, information needs, the experience of trial participation and impact of trial participation. Subthemes are presented in the manuscript. Conclusion To make fully informed decisions about trial participation, patients required the simplification of trial information and wanted more information about side effects, their response to trial treatment and the overall trial progress throughout the trial. Patients highlighted the need for improvement for the support provided to their family and friends.

AB - Objectives The study aimed to explore patients' experiences of experimental cancer medicine (ECM) clinical trials. Design The study's design was qualitative. Two focus groups with patients were undertaken followed by semistructured interviews, to explore patients' experiences of ECM clinical trials. Interviews and focus groups were audiorecorded and transcribed verbatim. Data were analysed using thematic analysis. Setting A regional cancer centre (tertiary care) in North-West England. Participants Twelve patients (aged 52-79) participated in one of the two focus groups and 22 patients (aged 42-83) participated in interviews. Primary outcome measure Patients' experiences of an ECM trial. Results Four main themes were identified from the analysis: decision making, information needs, the experience of trial participation and impact of trial participation. Subthemes are presented in the manuscript. Conclusion To make fully informed decisions about trial participation, patients required the simplification of trial information and wanted more information about side effects, their response to trial treatment and the overall trial progress throughout the trial. Patients highlighted the need for improvement for the support provided to their family and friends.

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KW - clinical trials

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JO - BMJ Open

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Oncology patients' experiences in experimental medicine cancer trials: a qualitative study

Abstract

Keywords

ASJC Scopus subject areas

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