Oncogenic role of nucleophosmin/B23

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39 Citations (Scopus)

Abstract

Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis.
Original languageEnglish
Pages (from-to)285-293
Number of pages9
JournalChang Gung Medical Journal
Volume30
Issue number4
Publication statusPublished - 1 Jul 2007
Externally publishedYes

Keywords

  • Nucleolus
  • Nucleophosmin/B23
  • Tumorigenesis

ASJC Scopus subject areas

  • Medicine(all)

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