Oleanolic acid exerts osteoprotective effects and modulates vitamin D metabolism.

Sisi Cao, Xiaoli Dong, Ming Xian Ho, Wenxuan Yu, Ka Chun Wong, Xin Sheng Yao, Man Sau Wong (Corresponding Author)

Research output: Journal article publicationJournal articleAcademic researchpeer-review

Abstract

Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)₂D₃ and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats. In addition, OA significantly increased renal CYP27B1 mRNA and promoter activity, and suppressed CYP24A1 mRNA and protein expressions in human proximal tubule HKC-8 cells. OA exerted bone protective effects in mature OVX mice and aged female rats. This action on bone might be, at least in part, associated with its effects on Ca and vitamin D metabolism. The present findings suggest that OA is a potential drug candidate for the management of postmenopausal osteoporosis.
Original languageEnglish
Article numberPMID: 29470404
Number of pages20
JournalNutrients
Volume10
Issue number2
DOIs
Publication statusPublished - 22 Feb 2018

ASJC Scopus subject areas

  • Pharmacology

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