Oleanolic acid exerts osteoprotective effects and modulates vitamin D metabolism

Sisi Cao, Xiao Li Dong, Ming Xian Ho, Wen Xuan Yu, Ka Chun Wong, Xin Sheng Yao, Man Sau Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)2D3 and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats. In addition, OA significantly increased renal CYP27B1 mRNA and promoter activity, and suppressed CYP24A1 mRNA and protein expressions in human proximal tubule HKC-8 cells. OA exerted bone protective effects in mature OVX mice and aged female rats. This action on bone might be, at least in part, associated with its effects on Ca and vitamin D metabolism. The present findings suggest that OA is a potential drug candidate for the management of postmenopausal osteoporosis.

Original languageEnglish
Article number247
JournalNutrients
Volume10
Issue number2
DOIs
Publication statusPublished - 22 Feb 2018

Keywords

  • Aging
  • Calcium
  • Oleanolic acid
  • Osteoporosis
  • Ovariectomised
  • vitamin D

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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