Obesity and COVID-19 in adult patients with diabetes

Peihua Cao, Ying Song, ZHUANG Zian, Jinjun Ran, Lin Xu, Ying Geng, Lefei Han, Shi Zhao, Jing Qin, Daihai He, Fengfu Wu, Lin Yang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Obesity has caused wide concerns due to its high prevalence in patients with severe coronavirus disease 2019 (COVID-19). Coexistence of diabetes and obesity could cause an even higher risk of severe outcomes due to immunity dysfunction. We conducted a retrospective study in 1,637 adult patients who were admitted into an acute hospital in Wuhan, China. Propensity score– matched logistic regression was used to estimate the risks of severe pneumonia and requiring in-hospital oxygen therapy associated with obesity. After adjustment for age, sex, and comorbidities, obesity was significantly associated with higher odds of severe pneumonia (odds ratio [OR] 1.47 [95% CI 1.15–1.88]; P 5 0.002) and oxygen therapy (OR 1.40 [95% CI 1.10–1.79]; P 5 0.007). Higher ORs of severe pneumonia due to obesity were observed in men, older adults, and those with diabetes. Among patients with diabetes, overweight increased the odds of requiring in-hospital oxygen therapy by 0.68 times (P 5 0.014) and obesity increased the odds by 1.06 times (P 5 0.028). A linear dose-response curve between BMI and severe outcomes was observed in all patients, whereas a U-shaped curve was observed in those with diabetes. Our findings provide important evidence to support obesity as an independent risk factor for severe outcomes of COVID-19 infection in the early phase of the ongoing pandemic.

Original languageEnglish
Pages (from-to)1061-1069
Number of pages9
JournalDiabetes
Volume70
Issue number5
DOIs
Publication statusPublished - Feb 2021

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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