Null-method in immersion refractometry for biophysical measurement of cryptosporidium and giardia lamblia

L. K. Chin, T. C. Ayi, P. H. Yap, A. Q. Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)

Abstract

This paper presents an on-chip null-method immersion refractometer for the measurement of size, shape and refractive index of protozoa in treated water. The key features of the on-chip immersion refractometer include (1) multiple single cyst trapping sites, which enable the measurement of multiple sample per test; and (2) zig-zag micromixer, which enables the refractive index variation of external medium as the key component of immersion refractometry. The results show that Cryptosporidium parvum oocysts have size of 3 to 7 μm, spherical with ovality lower than 0.3, and refractive index of 1.418. Giardia lamblia cysts have size of 8 to 12 μm, oval with ovality higher than 0.3, and refractive index of 1.433. The refractive i ndices of the samples are measured with high precision of < 10-3.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages707-709
Number of pages3
Publication statusPublished - Oct 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2 Oct 20116 Oct 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Country/TerritoryUnited States
CitySeattle, WA
Period2/10/116/10/11

Keywords

  • Cryptosporidium
  • Giardia lamblia
  • Immersion refractometer
  • Protozoa

ASJC Scopus subject areas

  • Control and Systems Engineering

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