Nucleation Domains in Biomineralization: Biomolecular Sequence and Conformational Features

Yawen Huang, Xinyue Zhang, Ruiqi Mao, Dongxuan Li, Fengxiong Luo, Ling Wang, Yafang Chen, Jian Lu, Xiang Ge, Yue Liu, Xusheng Yang, Yujiang Fan, Xingdong Zhang, Kefeng Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Biomolecules play a vital role in the regulation of biomineralization. However, the characteristics of practical nucleation domains are still sketchy. Herein, the effects of the representative biomolecular sequence and conformations on calcium phosphate (Ca-P) nucleation and mineralization are investigated. The results of computer simulations and experiments prove that the line in the arrangement of dual acidic/essential amino acids with a single interval (Bc (Basic) -N (Neutral) -Bc-N-Ac (Acidic)- NN-Ac-N) is most conducive to the nucleation. 2α-helix conformation can best induce Ca-P ion cluster formation and nucleation. “Ac- × × × -Bc” sequences with α-helix are found to be the features of efficient nucleation domains, in which process, molecular recognition plays a non-negligible role. It further indicates that the sequence determines the potential of nucleation/mineralization of biomolecules, and conformation determines the ability of that during functional execution. The findings will guide the synthesis of biomimetic mineralized materials with improved performance for bone repair.

Original languageEnglish
Pages (from-to)689-705
Number of pages17
JournalInorganic Chemistry
Volume63
Issue number1
DOIs
Publication statusPublished - 8 Jan 2024

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Nucleation Domains in Biomineralization: Biomolecular Sequence and Conformational Features'. Together they form a unique fingerprint.

Cite this