Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen

Dongwon Kim; Jong Min Kim; Youngmoo Jeon; Jeongyeon Lee; Jiseop Oh; Wytse Hooch Antink; Daekyu Kim; Yuanzhe Piao

doi:10.1016/j.snb.2017.12.066

Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen

Dongwon Kim
, Jong Min Kim
, Youngmoo Jeon
, Jeongyeon Lee
, Jiseop Oh
, Wytse Hooch Antink
, Daekyu Kim
, Yuanzhe Piao

Research output: Journal article publication › Journal article › Academic research › peer-review

92 Citations (Scopus)

Abstract

The determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for the electrochemical determination of AC. The electrode material is prepared by a two-step activation process, which involves the initial activation of kelp powder with ZnCl₂, followed by an activation step with KOH. The activation procedure greatly increased the overall pore volume and specific surface area. The characterizations of ZnCl₂-KOH activated kelp carbon (ZKAKC) were conducted with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and electrochemical impedance spectroscopy (EIS). The electrochemical characterization of ZKAKC was performed with cyclic voltammetry (CV) analysis of potassium ferricyanide. The sensing ability of ZKAKC/GCE toward acetaminophen was conducted using CV analysis and differential pulse voltammetry (DPV). The modified electrode showed high sensitivity, selectivity and a good detection limit for the determination acetaminophen with the detection limit of 0.004 μM. Also, the modified electrode showed good result toward acetaminophen even in the presence of ascorbic acid and dopamine with the detection limit of 0.007 μM. For the evaluation of sensing ability as an actual electrochemical sensor, a real sample test was conducted. The electrochemical performance was enhanced due to the increased physical and electrochemical surface area, which occurred during the two-step activation process. This approach for producing activated carbon is crucial for future development and can be applied to different carbon source materials.

Original language	English
Pages (from-to)	50-58
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	259
DOIs	https://doi.org/10.1016/j.snb.2017.12.066
Publication status	Published - 15 Apr 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acetaminophen
Activation
Biomass-derived carbon
Electrochemical sensor
Modified electrode

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

More information

10.1016/j.snb.2017.12.066

Cite this

@article{adbd4579e2e14779a9f18fd3a0f33d22,

title = "Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen",

abstract = "The determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for the electrochemical determination of AC. The electrode material is prepared by a two-step activation process, which involves the initial activation of kelp powder with ZnCl2, followed by an activation step with KOH. The activation procedure greatly increased the overall pore volume and specific surface area. The characterizations of ZnCl2-KOH activated kelp carbon (ZKAKC) were conducted with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and electrochemical impedance spectroscopy (EIS). The electrochemical characterization of ZKAKC was performed with cyclic voltammetry (CV) analysis of potassium ferricyanide. The sensing ability of ZKAKC/GCE toward acetaminophen was conducted using CV analysis and differential pulse voltammetry (DPV). The modified electrode showed high sensitivity, selectivity and a good detection limit for the determination acetaminophen with the detection limit of 0.004 μM. Also, the modified electrode showed good result toward acetaminophen even in the presence of ascorbic acid and dopamine with the detection limit of 0.007 μM. For the evaluation of sensing ability as an actual electrochemical sensor, a real sample test was conducted. The electrochemical performance was enhanced due to the increased physical and electrochemical surface area, which occurred during the two-step activation process. This approach for producing activated carbon is crucial for future development and can be applied to different carbon source materials.",

keywords = "Acetaminophen, Activation, Biomass-derived carbon, Electrochemical sensor, Modified electrode",

author = "Dongwon Kim and Kim, \{Jong Min\} and Youngmoo Jeon and Jeongyeon Lee and Jiseop Oh and \{Hooch Antink\}, Wytse and Daekyu Kim and Yuanzhe Piao",

note = "Funding Information: This research was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science , ICT and Future Planning, Republic of Korea , as Global Frontier Project (CISS-2012M3A6A6054186) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2015R1D1A1A01060398 ). Funding Information: This research was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT and Future Planning, Republic of Korea, as Global Frontier Project (CISS-2012M3A6A6054186) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01060398). Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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doi = "10.1016/j.snb.2017.12.066",

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T1 - Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen

AU - Kim, Dongwon

AU - Kim, Jong Min

AU - Jeon, Youngmoo

AU - Lee, Jeongyeon

AU - Oh, Jiseop

AU - Hooch Antink, Wytse

AU - Kim, Daekyu

AU - Piao, Yuanzhe

N1 - Funding Information: This research was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science , ICT and Future Planning, Republic of Korea , as Global Frontier Project (CISS-2012M3A6A6054186) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2015R1D1A1A01060398 ). Funding Information: This research was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT and Future Planning, Republic of Korea, as Global Frontier Project (CISS-2012M3A6A6054186) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01060398). Publisher Copyright: © 2017 Elsevier B.V.

PY - 2018/4/15

Y1 - 2018/4/15

N2 - The determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for the electrochemical determination of AC. The electrode material is prepared by a two-step activation process, which involves the initial activation of kelp powder with ZnCl2, followed by an activation step with KOH. The activation procedure greatly increased the overall pore volume and specific surface area. The characterizations of ZnCl2-KOH activated kelp carbon (ZKAKC) were conducted with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and electrochemical impedance spectroscopy (EIS). The electrochemical characterization of ZKAKC was performed with cyclic voltammetry (CV) analysis of potassium ferricyanide. The sensing ability of ZKAKC/GCE toward acetaminophen was conducted using CV analysis and differential pulse voltammetry (DPV). The modified electrode showed high sensitivity, selectivity and a good detection limit for the determination acetaminophen with the detection limit of 0.004 μM. Also, the modified electrode showed good result toward acetaminophen even in the presence of ascorbic acid and dopamine with the detection limit of 0.007 μM. For the evaluation of sensing ability as an actual electrochemical sensor, a real sample test was conducted. The electrochemical performance was enhanced due to the increased physical and electrochemical surface area, which occurred during the two-step activation process. This approach for producing activated carbon is crucial for future development and can be applied to different carbon source materials.

AB - The determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for the electrochemical determination of AC. The electrode material is prepared by a two-step activation process, which involves the initial activation of kelp powder with ZnCl2, followed by an activation step with KOH. The activation procedure greatly increased the overall pore volume and specific surface area. The characterizations of ZnCl2-KOH activated kelp carbon (ZKAKC) were conducted with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and electrochemical impedance spectroscopy (EIS). The electrochemical characterization of ZKAKC was performed with cyclic voltammetry (CV) analysis of potassium ferricyanide. The sensing ability of ZKAKC/GCE toward acetaminophen was conducted using CV analysis and differential pulse voltammetry (DPV). The modified electrode showed high sensitivity, selectivity and a good detection limit for the determination acetaminophen with the detection limit of 0.004 μM. Also, the modified electrode showed good result toward acetaminophen even in the presence of ascorbic acid and dopamine with the detection limit of 0.007 μM. For the evaluation of sensing ability as an actual electrochemical sensor, a real sample test was conducted. The electrochemical performance was enhanced due to the increased physical and electrochemical surface area, which occurred during the two-step activation process. This approach for producing activated carbon is crucial for future development and can be applied to different carbon source materials.

KW - Acetaminophen

KW - Activation

KW - Biomass-derived carbon

KW - Electrochemical sensor

KW - Modified electrode

UR - https://www.scopus.com/pages/publications/85037980910

U2 - 10.1016/j.snb.2017.12.066

DO - 10.1016/j.snb.2017.12.066

M3 - Journal article

AN - SCOPUS:85037980910

SN - 0925-4005

VL - 259

SP - 50

EP - 58

JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen

Abstract

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Keywords

ASJC Scopus subject areas

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