TY - JOUR
T1 - Novel two-step activation of biomass-derived carbon for highly sensitive electrochemical determination of acetaminophen
AU - Kim, Dongwon
AU - Kim, Jong Min
AU - Jeon, Youngmoo
AU - Lee, Jeongyeon
AU - Oh, Jiseop
AU - Hooch Antink, Wytse
AU - Kim, Daekyu
AU - Piao, Yuanzhe
N1 - Funding Information:
This research was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science , ICT and Future Planning, Republic of Korea , as Global Frontier Project (CISS-2012M3A6A6054186) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( 2015R1D1A1A01060398 ).
Funding Information:
This research was supported by the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT and Future Planning, Republic of Korea, as Global Frontier Project (CISS-2012M3A6A6054186) and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2015R1D1A1A01060398).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2018/4/15
Y1 - 2018/4/15
N2 - The determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for the electrochemical determination of AC. The electrode material is prepared by a two-step activation process, which involves the initial activation of kelp powder with ZnCl2, followed by an activation step with KOH. The activation procedure greatly increased the overall pore volume and specific surface area. The characterizations of ZnCl2-KOH activated kelp carbon (ZKAKC) were conducted with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and electrochemical impedance spectroscopy (EIS). The electrochemical characterization of ZKAKC was performed with cyclic voltammetry (CV) analysis of potassium ferricyanide. The sensing ability of ZKAKC/GCE toward acetaminophen was conducted using CV analysis and differential pulse voltammetry (DPV). The modified electrode showed high sensitivity, selectivity and a good detection limit for the determination acetaminophen with the detection limit of 0.004 μM. Also, the modified electrode showed good result toward acetaminophen even in the presence of ascorbic acid and dopamine with the detection limit of 0.007 μM. For the evaluation of sensing ability as an actual electrochemical sensor, a real sample test was conducted. The electrochemical performance was enhanced due to the increased physical and electrochemical surface area, which occurred during the two-step activation process. This approach for producing activated carbon is crucial for future development and can be applied to different carbon source materials.
AB - The determination of the concentration of acetaminophen (AC) in the human body is of significant importance to carefully monitor and regular drug safety and public health. However, most conventional methods are insufficient due to their time-consuming, expensive and complicated nature. In this study, we report a novel two-step activation of biomass-derived carbon for the electrochemical determination of AC. The electrode material is prepared by a two-step activation process, which involves the initial activation of kelp powder with ZnCl2, followed by an activation step with KOH. The activation procedure greatly increased the overall pore volume and specific surface area. The characterizations of ZnCl2-KOH activated kelp carbon (ZKAKC) were conducted with scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Brunauer-Emmett-Teller (BET) surface area analysis, and electrochemical impedance spectroscopy (EIS). The electrochemical characterization of ZKAKC was performed with cyclic voltammetry (CV) analysis of potassium ferricyanide. The sensing ability of ZKAKC/GCE toward acetaminophen was conducted using CV analysis and differential pulse voltammetry (DPV). The modified electrode showed high sensitivity, selectivity and a good detection limit for the determination acetaminophen with the detection limit of 0.004 μM. Also, the modified electrode showed good result toward acetaminophen even in the presence of ascorbic acid and dopamine with the detection limit of 0.007 μM. For the evaluation of sensing ability as an actual electrochemical sensor, a real sample test was conducted. The electrochemical performance was enhanced due to the increased physical and electrochemical surface area, which occurred during the two-step activation process. This approach for producing activated carbon is crucial for future development and can be applied to different carbon source materials.
KW - Acetaminophen
KW - Activation
KW - Biomass-derived carbon
KW - Electrochemical sensor
KW - Modified electrode
UR - http://www.scopus.com/inward/record.url?scp=85037980910&partnerID=8YFLogxK
U2 - 10.1016/j.snb.2017.12.066
DO - 10.1016/j.snb.2017.12.066
M3 - Journal article
AN - SCOPUS:85037980910
SN - 0925-4005
VL - 259
SP - 50
EP - 58
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -