Novel structural co-expression analysis linking the NPM1-associated ribosomal biogenesis network to chronic myelogenous leukemia

Wing Chi Chan, Xihong Lin, Godwin Yung, Thomas Lui, Ya Ming Chiu, Fengfeng Wang, Nancy B.Y. Tsui, William C.S. Cho, Shea Ping Yip, Parco M. Siu, Sze Chuen Cesar Wong, Yat Ming Yung

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14 Citations (Scopus)


Co-expression analysis reveals useful dysregulation patterns of gene cooperativeness for understanding cancer biology and identifying new targets for treatment. We developed a structural strategy to identify co-expressed gene networks that are important for chronic myelogenous leukemia (CML). This strategy compared the distributions of expressional correlations between CML and normal states, and it identified a data-driven threshold to classify strongly co-expressed networks that had the best coherence with CML. Using this strategy, we found a transcriptome-wide reduction of co-expression connectivity in CML, reflecting potentially loosened molecular regulation. Conversely, when we focused on nucleophosmin 1 (NPM1) associated networks, NPM1 established more co-expression linkages with BCR-ABL pathways and ribosomal protein networks in CML than normal. This finding implicates a new role of NPM1 in conveying tumorigenic signals from the BCR-ABL oncoprotein to ribosome biogenesis, affecting cellular growth. Transcription factors may be regulators of the differential co-expression patterns between CML and normal.
Original languageEnglish
Article number10973
JournalScientific Reports
Publication statusPublished - 24 Jul 2015

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