Novel regulators of spermatogenesis

Kin Lam Fok, Hao Chen, Yechun Ruan, Hsiao Chang Chan

Research output: Journal article publicationReview articleAcademic researchpeer-review

25 Citations (Scopus)

Abstract

Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis.
Original languageEnglish
Pages (from-to)31-42
Number of pages12
JournalSeminars in Cell and Developmental Biology
Volume29
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • CD147
  • CFTR
  • NYD-SP8
  • Spermatogenesis
  • STK31
  • YWK-II

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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