Novel regulators of spermatogenesis

Kin Lam Fok; Hao Chen; Yechun Ruan; Hsiao Chang Chan

doi:10.1016/j.semcdb.2014.02.008

Novel regulators of spermatogenesis

Kin Lam Fok, Hao Chen, Yechun Ruan, Hsiao Chang Chan

Research output: Journal article publication › Review article › Academic research › peer-review

32 Citations (Scopus)

Abstract

Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis.

Original language	English
Pages (from-to)	31-42
Number of pages	12
Journal	Seminars in Cell and Developmental Biology
Volume	29
DOIs	https://doi.org/10.1016/j.semcdb.2014.02.008
Publication status	Published - 1 Jan 2014
Externally published	Yes

Keywords

CD147
CFTR
NYD-SP8
Spermatogenesis
STK31
YWK-II

ASJC Scopus subject areas

Developmental Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/j.semcdb.2014.02.008

Cite this

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abstract = "Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis.",

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AU - Chen, Hao

AU - Ruan, Yechun

AU - Chan, Hsiao Chang

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N2 - Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis.

AB - Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis.

KW - CD147

KW - CFTR

KW - NYD-SP8

KW - Spermatogenesis

KW - STK31

KW - YWK-II

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DO - 10.1016/j.semcdb.2014.02.008

M3 - Review article

C2 - 24594193

SN - 1084-9521

VL - 29

SP - 31

EP - 42

JO - Seminars in Cell Biology

JF - Seminars in Cell Biology

ER -

Novel regulators of spermatogenesis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

More information

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