Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Xiaomeng Guo; Ruishuang Ma; Meng Wang; Benson Wui-Man Lau; Xiaopeng Chen; Yue Li

doi:10.3389/fphar.2022.971444

Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Xiaomeng Guo, Ruishuang Ma, Meng Wang, Benson Wui-Man Lau, Xiaopeng Chen, Yue Li (Corresponding Author)

Research output: Journal article publication › Review article › Academic research › peer-review

3 Citations (Scopus)

Abstract

Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis. In particular, CTS’s profound physiological impact on various stem cell populations and their maintenance and fate determination could improve the efficiency and accuracy of stem cell therapy for high-incidence disease. However, as much promise CTS holds, these CTS-mediated processes are complex and multifactorial and many of the underlying mechanisms as well as their clinical significance for high-incidence diseases are not yet fully understood. This review aims to shed light on the impact and mechanisms of CTS on the actions of diverse stem cells and the involvement of CTS in the many processes of stem cell behavior and provide new insights for the application of CTS and stem cell therapy in treating high-incidence diseases.

Original language	English
Article number	971444
Journal	Frontiers in Pharmacology
Volume	13
DOIs	https://doi.org/10.3389/fphar.2022.971444
Publication status	Published - 15 Aug 2022

Keywords

apoptosis
cryptotanshinone
differentiation
high-incidence diseases
proliferation
self-renewal
stem cell

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

More information

10.3389/fphar.2022.971444

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title = "Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases",

abstract = "Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis. In particular, CTS{\textquoteright}s profound physiological impact on various stem cell populations and their maintenance and fate determination could improve the efficiency and accuracy of stem cell therapy for high-incidence disease. However, as much promise CTS holds, these CTS-mediated processes are complex and multifactorial and many of the underlying mechanisms as well as their clinical significance for high-incidence diseases are not yet fully understood. This review aims to shed light on the impact and mechanisms of CTS on the actions of diverse stem cells and the involvement of CTS in the many processes of stem cell behavior and provide new insights for the application of CTS and stem cell therapy in treating high-incidence diseases.",

keywords = "apoptosis, cryptotanshinone, differentiation, high-incidence diseases, proliferation, self-renewal, stem cell",

author = "Xiaomeng Guo and Ruishuang Ma and Meng Wang and \{Wui-Man Lau\}, Benson and Xiaopeng Chen and Yue Li",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No. 82073832 to YL; 81903915 to XC); Tianjin Natural Science Fund for Distinguished Young Scholars (Grant No. 20JCJQJC00070 to YL); Tianjin Municipal Education Commission Scientific Research Project (Natural Science, Grant No. 2019ZD11 to YL). Hong Kong General Research Fund (No. 15105621 to WM-L). Publisher Copyright: Copyright {\textcopyright} 2022 Guo, Ma, Wang, Wui-Man Lau, Chen and Li.",

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T1 - Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

AU - Guo, Xiaomeng

AU - Ma, Ruishuang

AU - Wang, Meng

AU - Wui-Man Lau, Benson

AU - Chen, Xiaopeng

AU - Li, Yue

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No. 82073832 to YL; 81903915 to XC); Tianjin Natural Science Fund for Distinguished Young Scholars (Grant No. 20JCJQJC00070 to YL); Tianjin Municipal Education Commission Scientific Research Project (Natural Science, Grant No. 2019ZD11 to YL). Hong Kong General Research Fund (No. 15105621 to WM-L). Publisher Copyright: Copyright © 2022 Guo, Ma, Wang, Wui-Man Lau, Chen and Li.

PY - 2022/8/15

Y1 - 2022/8/15

N2 - Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis. In particular, CTS’s profound physiological impact on various stem cell populations and their maintenance and fate determination could improve the efficiency and accuracy of stem cell therapy for high-incidence disease. However, as much promise CTS holds, these CTS-mediated processes are complex and multifactorial and many of the underlying mechanisms as well as their clinical significance for high-incidence diseases are not yet fully understood. This review aims to shed light on the impact and mechanisms of CTS on the actions of diverse stem cells and the involvement of CTS in the many processes of stem cell behavior and provide new insights for the application of CTS and stem cell therapy in treating high-incidence diseases.

AB - Cryptotanshinone (CTS), a diterpenoid quinone, is found mostly in Salvia miltiorrhiza Bunge (S. miltiorrhiza) and plays a crucial role in many cellular processes, such as cell proliferation/self-renewal, differentiation and apoptosis. In particular, CTS’s profound physiological impact on various stem cell populations and their maintenance and fate determination could improve the efficiency and accuracy of stem cell therapy for high-incidence disease. However, as much promise CTS holds, these CTS-mediated processes are complex and multifactorial and many of the underlying mechanisms as well as their clinical significance for high-incidence diseases are not yet fully understood. This review aims to shed light on the impact and mechanisms of CTS on the actions of diverse stem cells and the involvement of CTS in the many processes of stem cell behavior and provide new insights for the application of CTS and stem cell therapy in treating high-incidence diseases.

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KW - cryptotanshinone

KW - differentiation

KW - high-incidence diseases

KW - proliferation

KW - self-renewal

KW - stem cell

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DO - 10.3389/fphar.2022.971444

M3 - Review article

AN - SCOPUS:85136856040

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VL - 13

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

M1 - 971444

ER -

Novel perspectives on the therapeutic role of cryptotanshinone in the management of stem cell behaviors for high-incidence diseases

Abstract

Keywords

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