Novel nanofibrous scaffold to improve wound healing

Eva Yi Wah Mak; Woon Fong Leung

doi:10.1115/IMECE2013-64223

Novel nanofibrous scaffold to improve wound healing

Eva Yi Wah Mak, Woon Fong Leung

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

1 Citation (Scopus)

Abstract

An antibacterial and biocompatible scaffold for fibroblasts proliferation based on chitosan has been developed. Chitosan solution is electrospun into uniform fibers of 100-200 nm in diameter that mimic the extracellular matrix of human skin. The fibrous mats are successfully cross-linked to be stable in acidic solution, which can be used to treat acute wounds. The crosslinked fibrous mats display antibacterial properties toward Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The mechanical properties of fibrous mats are shown to be comparable to native skin dermis which protects the skin wound.

Original language	English
Title of host publication	Biomedical and Biotechnology Engineering
Publisher	American Society of Mechanical Engineers (ASME)
Volume	3 B
ISBN (Print)	9780791856222
DOIs	https://doi.org/10.1115/IMECE2013-64223
Publication status	Published - 1 Jan 2013
Event	ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013 - San Diego, CA, United States Duration: 15 Nov 2013 → 21 Nov 2013

Conference

Conference	ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013
Country/Territory	United States
City	San Diego, CA
Period	15/11/13 → 21/11/13

ASJC Scopus subject areas

Mechanical Engineering

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10.1115/IMECE2013-64223

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title = "Novel nanofibrous scaffold to improve wound healing",

abstract = "An antibacterial and biocompatible scaffold for fibroblasts proliferation based on chitosan has been developed. Chitosan solution is electrospun into uniform fibers of 100-200 nm in diameter that mimic the extracellular matrix of human skin. The fibrous mats are successfully cross-linked to be stable in acidic solution, which can be used to treat acute wounds. The crosslinked fibrous mats display antibacterial properties toward Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The mechanical properties of fibrous mats are shown to be comparable to native skin dermis which protects the skin wound.",

author = "Mak, {Eva Yi Wah} and Leung, {Woon Fong}",

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AU - Leung, Woon Fong

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AB - An antibacterial and biocompatible scaffold for fibroblasts proliferation based on chitosan has been developed. Chitosan solution is electrospun into uniform fibers of 100-200 nm in diameter that mimic the extracellular matrix of human skin. The fibrous mats are successfully cross-linked to be stable in acidic solution, which can be used to treat acute wounds. The crosslinked fibrous mats display antibacterial properties toward Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The mechanical properties of fibrous mats are shown to be comparable to native skin dermis which protects the skin wound.

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U2 - 10.1115/IMECE2013-64223

DO - 10.1115/IMECE2013-64223

M3 - Conference article published in proceeding or book

SN - 9780791856222

VL - 3 B

BT - Biomedical and Biotechnology Engineering

PB - American Society of Mechanical Engineers (ASME)

T2 - ASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013

Y2 - 15 November 2013 through 21 November 2013

ER -

Novel nanofibrous scaffold to improve wound healing

Abstract

Conference

ASJC Scopus subject areas

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