Novel nanofibrous scaffold to improve wound healing

Eva Yi Wah Mak, Woon Fong Leung

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

1 Citation (Scopus)


An antibacterial and biocompatible scaffold for fibroblasts proliferation based on chitosan has been developed. Chitosan solution is electrospun into uniform fibers of 100-200 nm in diameter that mimic the extracellular matrix of human skin. The fibrous mats are successfully cross-linked to be stable in acidic solution, which can be used to treat acute wounds. The crosslinked fibrous mats display antibacterial properties toward Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli. The mechanical properties of fibrous mats are shown to be comparable to native skin dermis which protects the skin wound.
Original languageEnglish
Title of host publicationBiomedical and Biotechnology Engineering
PublisherAmerican Society of Mechanical Engineers (ASME)
Volume3 B
ISBN (Print)9780791856222
Publication statusPublished - 1 Jan 2013
EventASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013 - San Diego, CA, United States
Duration: 15 Nov 201321 Nov 2013


ConferenceASME 2013 International Mechanical Engineering Congress and Exposition, IMECE 2013
Country/TerritoryUnited States
CitySan Diego, CA

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this