Abstract
Two novel Gd(III) complexes with functionalised polyaminocarboxylate macrocycles, 1,4,7-tris(carboxymethyl)-9,24-dioxo-14,19-dioxa-1,4,7,10,23- pentaazacyclododecane (L1) and 1,4,7-tris(carboxymethyl)-9,25-dioxo- 14,17,20-trioxa-1,4,7,10,23- pentaazacyclotridecane (L2), were prepared in good yield. Their potential use as magnetic resonance imaging (MRI) contrast agents (CAs) was evaluated by investigating their relaxation behaviour as a function of pH, temperature and magnetic field strength. The 1/T1proton relaxivities at 20 MHz and 25°C of GdL1(5.87 mM-1s-1) and GdL2(6.14 mM-1s-1) were found to be significantly higher than the clinically used Gd 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd(DOTA)-) and Gd diethylenetriaminepentaethanoic acid (Gd(DTPA)2-). The complexes possess one water molecule in the inner coordination sphere whose mean residence lifetime was estimated to be 1.1 and 1.5 μs at 25°C by variable temperature (VT)17O NMR spectroscopy.
Original language | English |
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Pages (from-to) | 677-682 |
Number of pages | 6 |
Journal | Journal of Inorganic Biochemistry |
Volume | 98 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 May 2004 |
Externally published | Yes |
Keywords
- Contrast agent
- Gadolinium
- Macrocycle
- Magnetic resonance imaging
- Polyaminocarboxylate
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry