Novel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents

Kannie Wai Yan Chan, Serena Barra, Mauro Botta, Wing Tak Wong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

18 Citations (Scopus)

Abstract

Two novel Gd(III) complexes with functionalised polyaminocarboxylate macrocycles, 1,4,7-tris(carboxymethyl)-9,24-dioxo-14,19-dioxa-1,4,7,10,23- pentaazacyclododecane (L1) and 1,4,7-tris(carboxymethyl)-9,25-dioxo- 14,17,20-trioxa-1,4,7,10,23- pentaazacyclotridecane (L2), were prepared in good yield. Their potential use as magnetic resonance imaging (MRI) contrast agents (CAs) was evaluated by investigating their relaxation behaviour as a function of pH, temperature and magnetic field strength. The 1/T1proton relaxivities at 20 MHz and 25°C of GdL1(5.87 mM-1s-1) and GdL2(6.14 mM-1s-1) were found to be significantly higher than the clinically used Gd 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Gd(DOTA)-) and Gd diethylenetriaminepentaethanoic acid (Gd(DTPA)2-). The complexes possess one water molecule in the inner coordination sphere whose mean residence lifetime was estimated to be 1.1 and 1.5 μs at 25°C by variable temperature (VT)17O NMR spectroscopy.
Original languageEnglish
Pages (from-to)677-682
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume98
Issue number5
DOIs
Publication statusPublished - 1 May 2004
Externally publishedYes

Keywords

  • Contrast agent
  • Gadolinium
  • Macrocycle
  • Magnetic resonance imaging
  • Polyaminocarboxylate

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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