Novel core-shell nanoparticles and their application in high-capacity immobilization of enzymes

Xuepu Mao, Jinfeng Huang, Man Fai Leung, Zhiyun Du, Lin Ma, Zhishu Huang, Pei Li, Lianquan Gu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

20 Citations (Scopus)


Novel core-shell nanoparticles consisting of poly(methyl methacrylate) (PMMA) cores coated with synthetic polymer and biopolymer (polyethyleneimine, chitosan, and casein) shells were synthesized via direct graft copolymerization of methyl methacrylate from hydrophilic polymers in the absence of surfactant. Average hydrodynamic diameters of the nanoparticles ranged from 163 to 263 nm. High-capacity (up to 530 mg/g) immobilizations of enzymes and high-activity retained percentage (Espe) (up to 90%) were achieved.
Original languageEnglish
Pages (from-to)229-246
Number of pages18
JournalApplied Biochemistry and Biotechnology
Issue number3
Publication statusPublished - 1 Dec 2006


  • Core shell
  • Immobilized cellulase
  • Nanoparticles
  • Poly(methyl methacrylate)

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology

Cite this