Nonlinear photoacoustic generation by pump-probe excitation

Fei Cao, Zhihai Qiu, Kinfung Wong, Puxiang Lai, Lei Sun

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review


Photoacoustic technique has undergone major developments in recent decades. Most of current photoacoustic systems work in the linear range, in which the photoacoustic amplitude increases proportionally to the increasing of illuminating light power. The imaging sensitivity and contrast, however, in this case are limited due to stronger background signals from intrinsic chromophores in biological tissue. The current work investigates the advantages of nonlinear photoacoustic generation compared to linear signal, by using a single-wavelength pump-probe and nanosecond-scale two-pulse excitation scheme. The results show that nonlinearity induced by this scheme yields higher detection sensitivity and contrast.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2019
EditorsLihong V. Wang, Alexander A. Oraevsky
ISBN (Electronic)9781510623989
Publication statusPublished - 1 Jan 2019
EventPhotons Plus Ultrasound: Imaging and Sensing 2019 - San Francisco, United States
Duration: 3 Feb 20196 Feb 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
Country/TerritoryUnited States
CitySan Francisco


  • Nonlinearity
  • Photoacoustic
  • Pump-probe

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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