Nickel-catalyzed asymmetric α-arylation of ketone enolates

Guoshu Chen; Fuk Yee Kwong; Hoi On Chan; Wing Yiu Yu; Albert S.C. Chan

doi:10.1039/b601691j

Nickel-catalyzed asymmetric α-arylation of ketone enolates

Guoshu Chen
, Fuk Yee Kwong
, Hoi On Chan
, Wing Yiu Yu
, Albert S.C. Chan

The Hong Kong Polytechnic University

Research output: Journal article publication › Journal article › Academic research › peer-review

111 Citations (Scopus)

Abstract

An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

Original language	English
Pages (from-to)	1413-1415
Number of pages	3
Journal	Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/b601691j
Publication status	Published - 24 Mar 2006

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b601691j

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title = "Nickel-catalyzed asymmetric α-arylation of ketone enolates",

abstract = "An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98\% ee and excellent yields.",

author = "Guoshu Chen and Kwong, \{Fuk Yee\} and Chan, \{Hoi On\} and Yu, \{Wing Yiu\} and Chan, \{Albert S.C.\}",

year = "2006",

month = mar,

day = "24",

doi = "10.1039/b601691j",

language = "English",

pages = "1413--1415",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Nickel-catalyzed asymmetric α-arylation of ketone enolates

AU - Chen, Guoshu

AU - Kwong, Fuk Yee

AU - Chan, Hoi On

AU - Yu, Wing Yiu

AU - Chan, Albert S.C.

PY - 2006/3/24

Y1 - 2006/3/24

N2 - An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

AB - An atropisomeric dipyridyldiphosphine, P-Phos, can effect highly enantioselective Ni-catalyzed α-arylation of ketone enolates with aryl halides to install an all-carbon quaternary stereogenic center in up to 98% ee and excellent yields.

UR - https://www.scopus.com/pages/publications/33645023302

U2 - 10.1039/b601691j

DO - 10.1039/b601691j

M3 - Journal article

C2 - 16550284

SN - 1359-7345

SP - 1413

EP - 1415

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

Nickel-catalyzed asymmetric α-arylation of ketone enolates

Abstract

ASJC Scopus subject areas

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