New secoiridoids from the fruits of Ligustrum lucidum

Zuo Cheng Qiu; Xiao Xiao Zhao; Qing Chang Wu; Jian Wu Fu; Yi Dai; Man Sau Wong; Xin Sheng Yao

doi:10.1080/10286020.2018.1454438

New secoiridoids from the fruits of Ligustrum lucidum

Zuo Cheng Qiu, Xiao Xiao Zhao, Qing Chang Wu, Jian Wu Fu, Yi Dai, Man Sau Wong, Xin Sheng Yao

Research output: Journal article publication › Journal article › Academic research › peer-review

7 Citations (Scopus)

Abstract

Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.

Original language	English
Pages (from-to)	431-438
Number of pages	8
Journal	Journal of Asian Natural Products Research
Volume	20
Issue number	5
DOIs	https://doi.org/10.1080/10286020.2018.1454438
Publication status	Published - 4 May 2018

Keywords

ligustri lucidi fructus
MC3T3-E1 cells
Oleaceae
osteogenic activity
secoiridoids

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

More information

10.1080/10286020.2018.1454438

Cite this

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title = "New secoiridoids from the fruits of Ligustrum lucidum",

abstract = "Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.",

keywords = "ligustri lucidi fructus, MC3T3-E1 cells, Oleaceae, osteogenic activity, secoiridoids",

author = "Qiu, {Zuo Cheng} and Zhao, {Xiao Xiao} and Wu, {Qing Chang} and Fu, {Jian Wu} and Yi Dai and Wong, {Man Sau} and Yao, {Xin Sheng}",

year = "2018",

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doi = "10.1080/10286020.2018.1454438",

language = "English",

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TY - JOUR

T1 - New secoiridoids from the fruits of Ligustrum lucidum

AU - Qiu, Zuo Cheng

AU - Zhao, Xiao Xiao

AU - Wu, Qing Chang

AU - Fu, Jian Wu

AU - Dai, Yi

AU - Wong, Man Sau

AU - Yao, Xin Sheng

PY - 2018/5/4

Y1 - 2018/5/4

N2 - Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.

AB - Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.

KW - ligustri lucidi fructus

KW - MC3T3-E1 cells

KW - Oleaceae

KW - osteogenic activity

KW - secoiridoids

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U2 - 10.1080/10286020.2018.1454438

DO - 10.1080/10286020.2018.1454438

M3 - Journal article

VL - 20

SP - 431

EP - 438

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

SN - 1028-6020

IS - 5

ER -

New secoiridoids from the fruits of Ligustrum lucidum

Abstract

Keywords

ASJC Scopus subject areas

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