New secoiridoids from the fruits of Ligustrum lucidum

Zuo Cheng Qiu, Xiao Xiao Zhao, Qing Chang Wu, Jian Wu Fu, Yi Dai, Man Sau Wong, Xin Sheng Yao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

7 Citations (Scopus)

Abstract

Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.
Original languageEnglish
Pages (from-to)431-438
Number of pages8
JournalJournal of Asian Natural Products Research
Volume20
Issue number5
DOIs
Publication statusPublished - 4 May 2018

Keywords

  • ligustri lucidi fructus
  • MC3T3-E1 cells
  • Oleaceae
  • osteogenic activity
  • secoiridoids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this