Abstract
Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.
Original language | English |
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Pages (from-to) | 431-438 |
Number of pages | 8 |
Journal | Journal of Asian Natural Products Research |
Volume | 20 |
Issue number | 5 |
DOIs | |
Publication status | Published - 4 May 2018 |
Keywords
- ligustri lucidi fructus
- MC3T3-E1 cells
- Oleaceae
- osteogenic activity
- secoiridoids
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry