New hierarchical approach for microaneurysms detection with matched filter and machine learning

Jiayi Wu, Jingmin Xin, Lai Hong, Jia You, Nanning Zheng

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

16 Citations (Scopus)

Abstract

Microaneurysms are regarded as the first signs of diabetic retinopathy (DR), but the microaneurysms are not clear in the color retinal images, and many researches were studied to detect and locate these lesions. In this paper, a new hierarchical computing-aided diagnosis approach is proposed for the microaneurysms detection by using the multi-scale and multi-orientation sum of matched filter (MMMF) and machine learning, where 37 dimensional features are extracted from each candidate. Furthermore, several classifiers such as the k-nearest neighbor (kNN), local linear discrimination analysis (LLDA) and support vector machine (SVM) are modified to distinguish the true microaneurysms from the false ones, which is a typical unbalanced classification problem. The effectiveness of the proposed method is verified through the training set of a publicly available database, and the experiment results show that the proposed method has better detection performance including the receiver operating characteristic (ROC) curve and the free-response receiver operating characteristic (FROC) curve. Moreover, the proposed method with 37 dimensional features outperforms that with other features and has a sensitivity from 1/8 to 8 with the average of all seven points being 0.286 tested on the same database.
Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
PublisherIEEE
Pages4322-4325
Number of pages4
Volume2015-November
ISBN (Electronic)9781424492718
DOIs
Publication statusPublished - 4 Nov 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - MiCo Center, Milano Congressi Center, Milan, Italy
Duration: 25 Aug 201529 Aug 2015

Conference

Conference37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
Country/TerritoryItaly
CityMilan
Period25/08/1529/08/15

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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