TY - JOUR
T1 - New applications of oleanolic acid and its derivatives as cardioprotective agents
T2 - A review of their therapeutic perspectives
AU - Sun, Ning
AU - Li, Dongli
AU - Chen, Xiaoqing
AU - Wu, Panpan
AU - Lu, Yu Jing
AU - Hou, Ning
AU - Chen, Wen Hua
AU - Wong, Wing Leung
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.
AB - Oleanolic acid is an analogue of pentacyclic triterpenoids. It has been used as a hepatic drug for over 20 years in China. Currently, there are only five approved drugs derived from pentacyclic triterpenoids, including oleanolic acid (liver diseases), asiaticoside (wound healing), glycyrrhizinate (liver diseases), isoglycyrrhizinate (liver disease) and sodium aescinate (hydrocephalus). To understand more about the bioactivity and functional mechanisms of oleanolic acid, it can be developed as a potent therapeutic agent, in particular, for the prevention and treatment of heart diseases that are the leading cause of death for people worldwide. The primary aim of this mini-review is to summarize the new applications of oleanolic acid and its derivatives as cardioprotective agents reported in recent years and to highlight their therapeutic perspectives in cardiovascular diseases.
KW - Asiaticoside
KW - Cardioprotective agents
KW - Cardiovascular diseases
KW - Hepatic drug
KW - Oleanolic acid
KW - Pentacyclic triterpenoids
UR - http://www.scopus.com/inward/record.url?scp=85076479334&partnerID=8YFLogxK
U2 - 10.2174/1381612825666191105112802
DO - 10.2174/1381612825666191105112802
M3 - Review article
C2 - 31692428
AN - SCOPUS:85076479334
SN - 1381-6128
VL - 25
SP - 3740
EP - 3750
JO - Current Pharmaceutical Design
JF - Current Pharmaceutical Design
IS - 35
ER -
