@article{49c47c8d55d8447e967d4cbe16852773,
title = "Neurosensory rehabilitation and olfactory network recovery in COVID-19-related olfactory dysfunction",
abstract = "Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm3 to 49.5 mm3 (120\%), left: 37.5 mm3 to 42 mm3 (12\%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6\%)].",
keywords = "COVID-19, Olfactory dysfunction, Resting-state fMRI, Smell training, Vitamin A",
author = "Chung, \{Tom Wai Hin\} and Hui Zhang and Wong, \{Fergus Kai Chuen\} and Siddharth Sridhar and Chan, \{Kwok Hung\} and Cheng, \{Vincent Chi Chung\} and Yuen, \{Kwok Yung\} and Hung, \{Ivan Fan Ngai\} and Mak, \{Henry Ka Fung\}",
note = "Funding Information: Funding: This work was supported by the Shaw Foundation Hong Kong; Michael Seak-Kan Tong; Richard Yu and Carol Yu; May Tam Mak Mei Yin; Jessie \& George Ho Charitable Foundation; Perfect Shape Medical Limited; Respiratory Viral Research Foundation; Hui Ming, Hui Hoy and Chow Sin Lan Charity Fund Limited; Sanming Project of Medicine in Shenzhen, China (SZSM201911014); High Level-Hospital Program, Health Commission of Guangdong Province, China; Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Diseases and Research Capability on Antimicrobial Resistance for the Department of Health of the Hong Kong Special Administrative Region Government; Theme-Based Research Scheme (T11/707/15) of the Research Grants Council of the Hong Kong Special Administrative Region Government, China. The funding sources played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jun,
doi = "10.3390/brainsci11060686",
language = "English",
volume = "11",
journal = "Brain Sciences",
issn = "2076-3425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}