Neurophysiological and neuroimaging markers of repetitive transcranial magnetic stimulation treatment response in major depressive disorder: A systematic review and meta-analysis of predictive modeling studies

Min Xia Jin, Penny Ping Qin, Adam Wei Li Xia, Rebecca Lai Di Kan, Bella Bing Bing Zhang, Alvin Hong Pui Tang, Ami Sin Man Li, Tim Tian Ze Lin, Cristian G. Giron, Jun Jie Pei, Georg S. Kranz (Corresponding Author)

Research output: Journal article publicationReview articleAcademic researchpeer-review

2 Citations (Scopus)

Abstract

Predicting repetitive transcranial magnetic stimulation (rTMS) treatment outcomes in major depressive disorder (MDD) could reduce the financial and psychological risks of treatment failure. We systematically reviewed and meta-analyzed studies that leveraged neurophysiological and neuroimaging markers to predict rTMS response in MDD. Five databases were searched from inception to May 25, 2023. The primary meta-analytic outcome was predictive accuracy pooled from classification models. Regression models were summarized qualitatively. A promising marker was identified if it showed a sensitivity and specificity of 80% or higher in at least two independent studies. Searching yielded 36 studies. Twenty-two classification modeling studies produced an estimated area under the summary receiver operating characteristic curve of 0.87 (95% CI = 0.83–0.92), with 86.8% sensitivity (95% CI = 80.6–91.2%) and 81.9% specificity (95% CI = 76.1–86.4%). Frontal theta cordance measured by electroencephalography is closest to proof of concept. Predicting rTMS response using neurophysiological and neuroimaging markers is promising for clinical decision-making. However, replications by different research groups are needed to establish rigorous markers.

Original languageEnglish
Article number105695
JournalNeuroscience and Biobehavioral Reviews
Volume162
DOIs
Publication statusPublished - Jul 2024

Keywords

  • Classification accuracy
  • Major depressive disorder
  • Neuroimaging
  • Neurophysiological markers
  • Predictive models
  • Repetitive transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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