Neurological Disorders

B. W. Man Lau; Suk Yu Yau; K. T. Po; K. F. So

doi:10.1016/B978-0-12-801977-1.00011-8

Neurological Disorders

B. W. Man Lau, Suk Yu Yau, K. T. Po, K. F. So

The Hong Kong Polytechnic University

Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research › peer-review

Abstract

The generation and functional integration of adult-born neurons in the hippocampus and subventricular zone suggest an important mechanism of neural plasticity in the adult brain. Dysregulation in adult neurogenesis has been commonly reported in several neurological disorders, suggesting its potential role in the development and pathology of the disorders. Adult neurogenesis might also be involved in the therapeutic process, thereby alleviating the neurological symptoms. We provide an overview of altered adult neurogenesis in animal models and human brains in neurodegenerative diseases, neurodevelopmental disorders, and brain injuries.

Original language	English
Title of host publication	Adult Neurogenesis in the Hippocampus
Subtitle of host publication	Health, Psychopathology, and Brain Disease
Publisher	Elsevier Inc.
Pages	249-275
Number of pages	27
ISBN (Electronic)	9780128019924
ISBN (Print)	9780128019771
DOIs	https://doi.org/10.1016/B978-0-12-801977-1.00011-8
Publication status	Published - 15 Apr 2016

Keywords

Adult neurogenesis
Hippocampus
Neurological disorders
Subventricular zone
Therapeutic treatment

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/B978-0-12-801977-1.00011-8

Cite this

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AU - Yau, Suk Yu

AU - Po, K. T.

AU - So, K. F.

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N2 - The generation and functional integration of adult-born neurons in the hippocampus and subventricular zone suggest an important mechanism of neural plasticity in the adult brain. Dysregulation in adult neurogenesis has been commonly reported in several neurological disorders, suggesting its potential role in the development and pathology of the disorders. Adult neurogenesis might also be involved in the therapeutic process, thereby alleviating the neurological symptoms. We provide an overview of altered adult neurogenesis in animal models and human brains in neurodegenerative diseases, neurodevelopmental disorders, and brain injuries.

AB - The generation and functional integration of adult-born neurons in the hippocampus and subventricular zone suggest an important mechanism of neural plasticity in the adult brain. Dysregulation in adult neurogenesis has been commonly reported in several neurological disorders, suggesting its potential role in the development and pathology of the disorders. Adult neurogenesis might also be involved in the therapeutic process, thereby alleviating the neurological symptoms. We provide an overview of altered adult neurogenesis in animal models and human brains in neurodegenerative diseases, neurodevelopmental disorders, and brain injuries.

KW - Adult neurogenesis

KW - Hippocampus

KW - Neurological disorders

KW - Subventricular zone

KW - Therapeutic treatment

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M3 - Chapter in an edited book (as author)

SN - 9780128019771

SP - 249

EP - 275

BT - Adult Neurogenesis in the Hippocampus

PB - Elsevier Inc.

ER -

Neurological Disorders

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

More information

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