NEUROINFLAMMATION IN POST-TRAUMATIC OSTEOARTHRITIS: VASCULAR CONNECTION

Siu Ling Yip; Yuqi Zhang; Lanlan Zhang; Man Ting Au; Lin Zhu; Chunyi Wen

doi:10.1016/j.joca.2025.02.195

NEUROINFLAMMATION IN POST-TRAUMATIC OSTEOARTHRITIS: VASCULAR CONNECTION

Siu Ling Yip, Yuqi Zhang, Lanlan Zhang, Man Ting Au, Lin Zhu, Chunyi Wen (Corresponding Author)

Department of Biomedical Engineering

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

Abstract

Osteoarthritis (OA) is a debilitating joint disease characterized by progressive cartilage breakdown, subchondral bone changes, and synovial inflammation, culminating in chronic pain that severely impairs physical function and quality of life. Recent evidence suggests that OA-associated pain also involves neuroinflammation and altered pain processing pathways in the central and peripheral nervous system. Despite its high prevalence, the underlying mechanisms of OA progression and pain remain poorly understood, hindering the development of effective treatments. This study aims to elucidate the mechanism of neuroinflammation in post-traumatic OA in a rat model.

Original language	English
Title of host publication	Osteoarthritis and Cartilage
Publisher	Elsevier B.V.
Pages	S141-S141
Volume	33
ISBN (Electronic)	1063-4584
DOIs	https://doi.org/10.1016/j.joca.2025.02.195
Publication status	Published - 23 Apr 2025

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10.1016/j.joca.2025.02.195

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@inproceedings{2e7c54be6163445b844a6aec7b678e9e,

title = "NEUROINFLAMMATION IN POST-TRAUMATIC OSTEOARTHRITIS: VASCULAR CONNECTION",

abstract = "Osteoarthritis (OA) is a debilitating joint disease characterized by progressive cartilage breakdown, subchondral bone changes, and synovial inflammation, culminating in chronic pain that severely impairs physical function and quality of life. Recent evidence suggests that OA-associated pain also involves neuroinflammation and altered pain processing pathways in the central and peripheral nervous system. Despite its high prevalence, the underlying mechanisms of OA progression and pain remain poorly understood, hindering the development of effective treatments. This study aims to elucidate the mechanism of neuroinflammation in post-traumatic OA in a rat model.",

author = "Yip, \{Siu Ling\} and Yuqi Zhang and Lanlan Zhang and Au, \{Man Ting\} and Lin Zhu and Chunyi Wen",

year = "2025",

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doi = "10.1016/j.joca.2025.02.195",

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AU - Yip, Siu Ling

AU - Zhang, Yuqi

AU - Zhang, Lanlan

AU - Au, Man Ting

AU - Zhu, Lin

AU - Wen, Chunyi

PY - 2025/4/23

Y1 - 2025/4/23

N2 - Osteoarthritis (OA) is a debilitating joint disease characterized by progressive cartilage breakdown, subchondral bone changes, and synovial inflammation, culminating in chronic pain that severely impairs physical function and quality of life. Recent evidence suggests that OA-associated pain also involves neuroinflammation and altered pain processing pathways in the central and peripheral nervous system. Despite its high prevalence, the underlying mechanisms of OA progression and pain remain poorly understood, hindering the development of effective treatments. This study aims to elucidate the mechanism of neuroinflammation in post-traumatic OA in a rat model.

AB - Osteoarthritis (OA) is a debilitating joint disease characterized by progressive cartilage breakdown, subchondral bone changes, and synovial inflammation, culminating in chronic pain that severely impairs physical function and quality of life. Recent evidence suggests that OA-associated pain also involves neuroinflammation and altered pain processing pathways in the central and peripheral nervous system. Despite its high prevalence, the underlying mechanisms of OA progression and pain remain poorly understood, hindering the development of effective treatments. This study aims to elucidate the mechanism of neuroinflammation in post-traumatic OA in a rat model.

U2 - 10.1016/j.joca.2025.02.195

DO - 10.1016/j.joca.2025.02.195

M3 - Conference article published in proceeding or book

VL - 33

SP - S141-S141

BT - Osteoarthritis and Cartilage

PB - Elsevier B.V.

ER -

NEUROINFLAMMATION IN POST-TRAUMATIC OSTEOARTHRITIS: VASCULAR CONNECTION

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