Near-Infrared and Visible Dual-Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes

Yik Hoi Yeung; Ho Fai Chau; Hei Yui Kai; Wanqi Zhou; Kaitlin Hao Yi Chan; Waygen Thor; Loïc J. Charbonnière; Fan Zhang; Yong Fan; Yue Wu; Ka Leung Wong

doi:10.1002/adom.202302070

Near-Infrared and Visible Dual-Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes

Yik Hoi Yeung, Ho Fai Chau, Hei Yui Kai, Wanqi Zhou, Kaitlin Hao Yi Chan, Waygen Thor, Loïc J. Charbonnière, Fan Zhang, Yong Fan, Yue Wu, Ka Leung Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

Abstract

The synthetic difficulty of target-specific lanthanide complexes, despite their unique characteristics, limits their use in in vitro/ in vivo studies and biomedical applications. With commercially available and affordable reagents, a facile synthetic approach is developed to modularly deploy nitrobenzoxadiazole and neodymium complexes onto bioactive peptides. The yielded probes show observable neodymium emission with specific localization to corresponding biotargets in vitro, which became the first example of a stable, water-soluble, and target-specific neodymium(III) complex applicable for in vitro imaging with detectable brightness.

Original language	English
Article number	2302070
Journal	Advanced Optical Materials
Volume	12
Issue number	9
DOIs	https://doi.org/10.1002/adom.202302070
Publication status	Published - 10 Feb 2024

Keywords

lanthanide probes
neodymium
NIR probes
nitrobenzoxadiazole
solid-phase peptide synthesis

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

More information

10.1002/adom.202302070

Cite this

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title = "Near-Infrared and Visible Dual-Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes",

abstract = "The synthetic difficulty of target-specific lanthanide complexes, despite their unique characteristics, limits their use in in vitro/ in vivo studies and biomedical applications. With commercially available and affordable reagents, a facile synthetic approach is developed to modularly deploy nitrobenzoxadiazole and neodymium complexes onto bioactive peptides. The yielded probes show observable neodymium emission with specific localization to corresponding biotargets in vitro, which became the first example of a stable, water-soluble, and target-specific neodymium(III) complex applicable for in vitro imaging with detectable brightness.",

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doi = "10.1002/adom.202302070",

language = "English",

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AU - Yeung, Yik Hoi

AU - Chau, Ho Fai

AU - Kai, Hei Yui

AU - Zhou, Wanqi

AU - Chan, Kaitlin Hao Yi

AU - Thor, Waygen

AU - Charbonnière, Loïc J.

AU - Zhang, Fan

AU - Fan, Yong

AU - Wu, Yue

AU - Wong, Ka Leung

PY - 2024/2/10

Y1 - 2024/2/10

N2 - The synthetic difficulty of target-specific lanthanide complexes, despite their unique characteristics, limits their use in in vitro/ in vivo studies and biomedical applications. With commercially available and affordable reagents, a facile synthetic approach is developed to modularly deploy nitrobenzoxadiazole and neodymium complexes onto bioactive peptides. The yielded probes show observable neodymium emission with specific localization to corresponding biotargets in vitro, which became the first example of a stable, water-soluble, and target-specific neodymium(III) complex applicable for in vitro imaging with detectable brightness.

AB - The synthetic difficulty of target-specific lanthanide complexes, despite their unique characteristics, limits their use in in vitro/ in vivo studies and biomedical applications. With commercially available and affordable reagents, a facile synthetic approach is developed to modularly deploy nitrobenzoxadiazole and neodymium complexes onto bioactive peptides. The yielded probes show observable neodymium emission with specific localization to corresponding biotargets in vitro, which became the first example of a stable, water-soluble, and target-specific neodymium(III) complex applicable for in vitro imaging with detectable brightness.

KW - lanthanide probes

KW - neodymium

KW - NIR probes

KW - nitrobenzoxadiazole

KW - solid-phase peptide synthesis

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U2 - 10.1002/adom.202302070

DO - 10.1002/adom.202302070

M3 - Journal article

AN - SCOPUS:85184488281

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VL - 12

JO - Advanced Optical Materials

JF - Advanced Optical Materials

IS - 9

M1 - 2302070

ER -

Near-Infrared and Visible Dual-Emitting Peptide by Modular Assembly of Nitrobenzoxadiazole and Neodymium Complexes

Abstract

Keywords

ASJC Scopus subject areas

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