Natural Xanthones from Garcinia mangostana with Multifunctional Activities for the Therapy of Alzheimer’s Disease

Sheng nan Wang, Qian Li, Ming hua Jing, Espargaró Alba, Xiao hong Yang, Raimon Sabaté, Yi fan Han, Rong biao Pi, Wen jian Lan, Xiao bo Yang, Jing kao Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

39 Citations (Scopus)

Abstract

Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named α-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and γ-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced β-amyloid (Aβ) aggregation and also β-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators. Among these compounds, α-Mangostin, Gartanin, Garcinone C and γ-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical than Trolox, and potent neuroprotective effects against glutamate-induced HT22 cell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species. Moreover, Gartanin, Garcinone C and γ-Mangostin could be able to penetrate the blood–brain barrier (BBB) in vitro. These findings suggest that the natural xanthones have multifunctional activities against Alzheimer’s disease (AD) and could be promising compounds for the therapy of AD.
Original languageEnglish
Pages (from-to)1806-1817
Number of pages12
JournalNeurochemical Research
Volume41
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • Alzheimer’s disease
  • Multifunction
  • Neuroprotection
  • Oxidative stress
  • Xanthones

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this