Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma

Lip Ket Chin; Hyungsoon Im; Sung Gyu Park; Benjamin Chousterman

Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma

Lip Ket Chin, Hyungsoon Im, Sung Gyu Park, Benjamin Chousterman

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

Abstract

Molecular analysis has been widely used for disease diagnosis and treatment efficacy analysis. Plasmonic biosensors are popular for molecular analysis because of their rapid detection and high sensitivity. This paper presents a nanoplasmonic biosensor combined with a chemifluorescence approach for multiplex molecular profiling in plasma samples. The nanoplasmonic biosensor significantly improves the detection sensitivity with the fluorescence signal being enhanced by ~300-fold. In the measurement of multiple cytokines' expression levels in patient plasma, the experimental results show that the nanoplasmonic biosensor achieves a limit of detection as low as 0.5 pg/mL. The assay time is as fast as 1 hour. We envisage that the developed nanoplasmonic biosensor has broad applications in disease diagnosis, including inflammation, cancer, or even infectious diseases.

Original language	English
Title of host publication	2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	140-143
Number of pages	4
ISBN (Electronic)	9784886864352
Publication status	Published - 2023
Event	22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 - Kyoto, Japan Duration: 25 Jun 2023 → 29 Jun 2023

Publication series

Name	2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

Conference

Conference	22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023
Country/Territory	Japan
City	Kyoto
Period	25/06/23 → 29/06/23

Keywords

biosensors
cytokine
molecular profiling
Nanoplasmonics

ASJC Scopus subject areas

Computer Science Applications
Electrical and Electronic Engineering
Control and Optimization
Instrumentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Chin, L. K., Im, H., Park, S. G., & Chousterman, B. (2023). Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma. In 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 (pp. 140-143). (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023). Institute of Electrical and Electronics Engineers Inc..

Chin, Lip Ket ; Im, Hyungsoon ; Park, Sung Gyu et al. / Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma. 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. Institute of Electrical and Electronics Engineers Inc., 2023. pp. 140-143 (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023).

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title = "Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma",

abstract = "Molecular analysis has been widely used for disease diagnosis and treatment efficacy analysis. Plasmonic biosensors are popular for molecular analysis because of their rapid detection and high sensitivity. This paper presents a nanoplasmonic biosensor combined with a chemifluorescence approach for multiplex molecular profiling in plasma samples. The nanoplasmonic biosensor significantly improves the detection sensitivity with the fluorescence signal being enhanced by \textasciitilde{}300-fold. In the measurement of multiple cytokines' expression levels in patient plasma, the experimental results show that the nanoplasmonic biosensor achieves a limit of detection as low as 0.5 pg/mL. The assay time is as fast as 1 hour. We envisage that the developed nanoplasmonic biosensor has broad applications in disease diagnosis, including inflammation, cancer, or even infectious diseases.",

keywords = "biosensors, cytokine, molecular profiling, Nanoplasmonics",

author = "Chin, \{Lip Ket\} and Hyungsoon Im and Park, \{Sung Gyu\} and Benjamin Chousterman",

note = "Publisher Copyright: {\textcopyright} 2023 IEEJ.; 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023 ; Conference date: 25-06-2023 Through 29-06-2023",

year = "2023",

language = "English",

series = "2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "140--143",

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Chin, LK, Im, H, Park, SG & Chousterman, B 2023, Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma. in 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, Institute of Electrical and Electronics Engineers Inc., pp. 140-143, 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023, Kyoto, Japan, 25/06/23.

Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma. / Chin, Lip Ket; Im, Hyungsoon; Park, Sung Gyu et al.
2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. Institute of Electrical and Electronics Engineers Inc., 2023. p. 140-143 (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

TY - GEN

T1 - Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma

AU - Chin, Lip Ket

AU - Im, Hyungsoon

AU - Park, Sung Gyu

AU - Chousterman, Benjamin

PY - 2023

Y1 - 2023

N2 - Molecular analysis has been widely used for disease diagnosis and treatment efficacy analysis. Plasmonic biosensors are popular for molecular analysis because of their rapid detection and high sensitivity. This paper presents a nanoplasmonic biosensor combined with a chemifluorescence approach for multiplex molecular profiling in plasma samples. The nanoplasmonic biosensor significantly improves the detection sensitivity with the fluorescence signal being enhanced by ~300-fold. In the measurement of multiple cytokines' expression levels in patient plasma, the experimental results show that the nanoplasmonic biosensor achieves a limit of detection as low as 0.5 pg/mL. The assay time is as fast as 1 hour. We envisage that the developed nanoplasmonic biosensor has broad applications in disease diagnosis, including inflammation, cancer, or even infectious diseases.

AB - Molecular analysis has been widely used for disease diagnosis and treatment efficacy analysis. Plasmonic biosensors are popular for molecular analysis because of their rapid detection and high sensitivity. This paper presents a nanoplasmonic biosensor combined with a chemifluorescence approach for multiplex molecular profiling in plasma samples. The nanoplasmonic biosensor significantly improves the detection sensitivity with the fluorescence signal being enhanced by ~300-fold. In the measurement of multiple cytokines' expression levels in patient plasma, the experimental results show that the nanoplasmonic biosensor achieves a limit of detection as low as 0.5 pg/mL. The assay time is as fast as 1 hour. We envisage that the developed nanoplasmonic biosensor has broad applications in disease diagnosis, including inflammation, cancer, or even infectious diseases.

KW - biosensors

KW - cytokine

KW - molecular profiling

KW - Nanoplasmonics

UR - https://www.scopus.com/pages/publications/85193547098

M3 - Conference article published in proceeding or book

AN - SCOPUS:85193547098

T3 - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

SP - 140

EP - 143

BT - 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023

Y2 - 25 June 2023 through 29 June 2023

ER -

Chin LK, Im H, Park SG, Chousterman B. Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma. In 2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 140-143. (2023 22nd International Conference on Solid-State Sensors, Actuators and Microsystems, Transducers 2023).

Nanoplasmonic Biosensor for Cytokine Profiling in Patient Plasma

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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