Nanoparticles for tracing acupuncture Meridians and Bonghan ducts

Hyeon Min Johng, Chang Hoon Lee, Jung Sun Yoo, Tae Jong Yoon, Hak Soo Shin, Byung Cheon Lee, Jin Kyu Lee, Jung Dae Kim, Wan Su Park, Kwang Sup Soh

Research output: Journal article publicationConference articleAcademic researchpeer-review

2 Citations (Scopus)


Nanoparticles are increasingly used in various fields, especially in biomedical research such as enzyme immobilization, contrast enhancing media, and imaging of cellular and molecular structures. We report on the use of fluorescent magnetic nanoparticles for tracing acupuncture meridians and their anatomical structures, that is, Bonghan ducts. By injecting nanoparticles into the acupuncture points (LR9) of mice we observed them at other acupoints (LR3) of the same liver meridian, which implied the propagation of nanoparticles along the meridian. Another use of nanoparticles was injecting them into a Bonghan corpuscle and observing them to flow along the Bonghan duct on the surface of mammalian internal organs. The third application was injecting them into lymph nodes so that Bonghan ducts inside lymphatic vessels were detected and visualized by the fluorescence of nanoparticles. Confocal laser scanning microscope images of cryo-sectioned specimens showed that the nanoparticles were preferentially taken up by Bonghan ducts. Transmission electron microscope images revealed the nanoparticles captured in the extra cellular matrix of Bonghan ducts.
Original languageEnglish
Pages (from-to)3584-3586
Number of pages3
JournalIFMBE Proceedings
Issue number1
Publication statusPublished - 1 Jan 2007
Externally publishedYes
Event10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of
Duration: 27 Aug 20061 Sep 2006


  • Acupuncture meridian
  • Bonghan duct
  • Electron-microscope
  • Lymph
  • Nanoparticles

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering


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