Nanoparticle enhanced surface plasmon resonance biosensing: Application of gold nanorods

Wing Cheung Law, Ken Tye Yong, Alexander Baev, Rui Hu, Paras N. Prasad

Research output: Journal article publicationJournal articleAcademic researchpeer-review

65 Citations (Scopus)

Abstract

In this report, we demonstrate the use of functionalized gold nanorods as amplification labels for ultra-sensitive surface plasmon resonance biosensing. Drastic sensitivity enhancement, owed to the electromagnetic interaction between the nanotag and the sensing film, was maximized using longitudinal plasmonic resonance of gold nanorods. The detection sensitivity of the nanorod-conjugated antibody is estimated to be ~40 pg/ml, which is 25-100 times more sensitive than the current reported values in the literature. This work paves the way to a new generation of ultra-sensitive nanoparticles-based biosensor platforms with maximized enhancement of sensitivity for ultra-fast screening and real-time detection of "hard-to-identify" biomolecules.
Original languageEnglish
Pages (from-to)19041-19046
Number of pages6
JournalOptics Express
Volume17
Issue number21
DOIs
Publication statusPublished - 12 Oct 2009
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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