Nanoparticle based fluorescence resonance energy transfer (FRET) for biosensing applications

Jingyu Shi, Feng Tian, Jing Lyu, Mo Yang

Research output: Journal article publicationReview articleAcademic researchpeer-review

159 Citations (Scopus)


In the past few decades, Förster resonance energy transfer (FRET) has been used as a powerful tool for providing nanoscale information in many biosensing and bioanalysis applications. The performance of FRET assays is mainly dependent on the design of donor and acceptor pairs. Recently, a series of nanoparticles start to be used in FRET assays including semiconductor quantum dots (QDs), graphene quantum dots (GQDs), upconversion nanoparticles (UCNPs), gold nanoparticles (AuNPs) and graphene oxide (GO). The rapid pace of development in nanoparticles provides a lot of opportunities to revolutionize FRET techniques. Many nanoparticle based FRET assays have also been developed for various biosensing applications with higher sensitivity and better stability compared with traditional organic fluorophore based FRET assays. This article reviews the recent progress of nanoparticle FRET assays and their applications in biosensing area.
Original languageEnglish
Pages (from-to)6989-7005
Number of pages17
JournalJournal of Materials Chemistry B
Issue number35
Publication statusPublished - 10 Jul 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)


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