Nanocrystalline β-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications

Kelvin Y. Xie, Yanbo Wang, Yonghao Zhao, Li Chang, Guocheng Wang, Zibin Chen, Yang Cao, Xiaozhou Liao, Enrique J. Lavernia, Ruslan Z. Valiev, Babak Sarrafpour, Hans Zoellner, Simon P. Ringer

Research output: Journal article publicationJournal articleAcademic researchpeer-review

55 Citations (Scopus)


High strength, low Young's modulus and good biocompatibility are desirable but difficult to simultaneously achieve in metallic implant materials for load bearing applications, and these impose significant challenges in material design. Here we report that a nano-grained β-Ti alloy prepared by high-pressure torsion exhibits remarkable mechanical and biological properties. The hardness and modulus of the nano-grained Ti alloy were respectively 23% higher and 34% lower than those of its coarse-grained counterpart. Fibroblast cell attachment and proliferation were enhanced, demonstrating good in vitro biocompatibility of the nano-grained Ti alloy, consistent with demonstrated increased nano-roughness on the nano-grained Ti alloy. Results suggest that the nano-grained β-Ti alloy may have significant application as an implant material in dental and orthopedic applications.

Original languageEnglish
Pages (from-to)3530-3536
Number of pages7
JournalMaterials Science and Engineering C
Issue number6
Publication statusPublished - 1 Aug 2013
Externally publishedYes


  • Cell attachment and proliferation
  • High-pressure torsion
  • Mechanical properties
  • Ti alloy

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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