Nano-optofluidics for single molecule detection and sorting

Y. Yang; J. M. Tsai; D. L. Kwong; A. Q. Liu

doi:10.1109/MEMSYS.2012.6170117

Nano-optofluidics for single molecule detection and sorting

Y. Yang, J. M. Tsai, D. L. Kwong, A. Q. Liu

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

1 Citation (Scopus)

Abstract

This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting.

Original language	English
Title of host publication	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages	156-159
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2012.6170117
Publication status	Published - Feb 2012
Externally published	Yes
Event	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France Duration: 29 Jan 2012 → 2 Feb 2012

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Country/Territory	France
City	Paris
Period	29/01/12 → 2/02/12

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

More information

10.1109/MEMSYS.2012.6170117

Cite this

Yang, Y., Tsai, J. M., Kwong, D. L., & Liu, A. Q. (2012). Nano-optofluidics for single molecule detection and sorting. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 (pp. 156-159). Article 6170117 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2012.6170117

@inproceedings{3b73baa127f74e34b457cfe57c912faf,

title = "Nano-optofluidics for single molecule detection and sorting",

abstract = "This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting.",

author = "Y. Yang and Tsai, \{J. M.\} and Kwong, \{D. L.\} and Liu, \{A. Q.\}",

year = "2012",

month = feb,

doi = "10.1109/MEMSYS.2012.6170117",

language = "English",

isbn = "9781467303248",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

pages = "156--159",

booktitle = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012",

note = "2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 ; Conference date: 29-01-2012 Through 02-02-2012",

}

Yang, Y, Tsai, JM, Kwong, DL & Liu, AQ 2012, Nano-optofluidics for single molecule detection and sorting. in 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012., 6170117, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 156-159, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 29/01/12. https://doi.org/10.1109/MEMSYS.2012.6170117

Nano-optofluidics for single molecule detection and sorting. / Yang, Y.; Tsai, J. M.; Kwong, D. L. et al.
2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012. 2012. p. 156-159 6170117 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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N2 - This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting.

AB - This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting.

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DO - 10.1109/MEMSYS.2012.6170117

M3 - Conference article published in proceeding or book

AN - SCOPUS:84860436912

SN - 9781467303248

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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BT - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

T2 - 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012

Y2 - 29 January 2012 through 2 February 2012

ER -

Nano-optofluidics for single molecule detection and sorting

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