Nano-optofluidics for single molecule detection

Y. Yang, J. M. Tsai, D. L. Kwong, A. Q. Liu

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

This paper reports a nano-optofluidic device with evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in a liquid can be detected although their size is smaller than the diffraction limit. We have demonstrated a successful imaging of 200-nm nanoparticles. In this nano-optofluidic TIR system, all samples focused in the liquids can be measured and counted rather than that detected only on the solid-liquid interface in conventional TIR microscope. It has wide range applications in single molecule detection, imaging and counting in near future.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1903-1905
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - Nov 2012
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: 28 Oct 20121 Nov 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Conference

Conference16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
Country/TerritoryJapan
CityOkinawa
Period28/10/121/11/12

Keywords

  • Evanescent wave
  • Nano-optofluidics
  • Nanoparticles

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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