N-terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence

Karen Ka Yan Kung; Kong Fan Wong; King Chi Leung; Man Kin Wong

doi:10.1039/c3cc42261e

N-terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence

Karen Ka Yan Kung, Kong Fan Wong, King Chi Leung, Man Kin Wong

Research output: Journal article publication › Journal article › Academic research › peer-review

31 Citations (Scopus)

Abstract

A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.

Original language	English
Pages (from-to)	6888-6890
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	61
DOIs	https://doi.org/10.1039/c3cc42261e
Publication status	Published - 7 Aug 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc42261e

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title = "N-terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence",

abstract = "A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.",

author = "Kung, {Karen Ka Yan} and Wong, {Kong Fan} and Leung, {King Chi} and Wong, {Man Kin}",

year = "2013",

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AU - Kung, Karen Ka Yan

AU - Wong, Kong Fan

AU - Leung, King Chi

AU - Wong, Man Kin

PY - 2013/8/7

Y1 - 2013/8/7

N2 - A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.

AB - A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed.

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DO - 10.1039/c3cc42261e

M3 - Journal article

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SP - 6888

EP - 6890

JO - Chemical Communications

JF - Chemical Communications

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ER -

N-terminal α-amino group modification of peptides by an oxime formation-exchange reaction sequence

Abstract

ASJC Scopus subject areas

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