TY - JOUR
T1 - Myelin Content and Gait Impairment in Older Adults with Cerebral Small Vessel Disease and Mild Cognitive Impairment
AU - Boa Sorte Silva, Nárlon C.
AU - Dao, Elizabeth
AU - Hsu, Chun Liang
AU - Tam, Roger C.
AU - Stein, Ryan
AU - Alkeridy, Walid
AU - Laule, Cornelia
AU - Vavasour, Irene M.
AU - Liu-Ambrose, Teresa
N1 - Funding Information:
NCBSS is a post-doctoral fellow jointly funded by the Michael Smith Health Research BC, the Canadians for Leading Edge Alzheimer Research, and the Canadian Institutes of Health Research. ED is a Michael Smith Health Research BC post-doctoral fellow. TL-A is a Canada Research Chair (Tier I) in Healthy Aging . This work was supported by the Heart and Stroke Foundation of Canada and the Alzheimer Society Research Program to TL-A. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
Publisher Copyright:
© 2022
PY - 2022/11
Y1 - 2022/11
N2 - We investigated whether myelin is associated with gait parameters in older adults with cerebral small vessel disease (cSVD). Cross-sectional data from sixty-four participants with cSVD and mild cognitive impairment were analyzed. Myelin was assessed via MRI multi-echo gradient and spin echo T2 relaxation sequence, indexed as myelin water fraction (MWF). Gait was assessed using an electronic walkway. Hierarchical regression models adjusting for total intracranial volume, age, sex, Mini-Mental State Examination, and body mass index were conducted to determine associations between MWF and gait parameters. Significant models were further adjusted for white matter hyperintensities. Sixty-four participants were included (mean [SD], age = 75.2y [5.4], 62.5% female). In adjusted models, lower MWF in the cingulum (p = 0.015), superior longitudinal fasciculus (p = 0.034), posterior corona radiata (p = 0.039), and body of the corpus callosum (p = 0.040) was associated with higher cycle time variability. White matter hyperintensities weakened these associations. Lower myelin in specific white matter tracts may contribute to higher gait variability, increasing the overall risk of mobility impairment.
AB - We investigated whether myelin is associated with gait parameters in older adults with cerebral small vessel disease (cSVD). Cross-sectional data from sixty-four participants with cSVD and mild cognitive impairment were analyzed. Myelin was assessed via MRI multi-echo gradient and spin echo T2 relaxation sequence, indexed as myelin water fraction (MWF). Gait was assessed using an electronic walkway. Hierarchical regression models adjusting for total intracranial volume, age, sex, Mini-Mental State Examination, and body mass index were conducted to determine associations between MWF and gait parameters. Significant models were further adjusted for white matter hyperintensities. Sixty-four participants were included (mean [SD], age = 75.2y [5.4], 62.5% female). In adjusted models, lower MWF in the cingulum (p = 0.015), superior longitudinal fasciculus (p = 0.034), posterior corona radiata (p = 0.039), and body of the corpus callosum (p = 0.040) was associated with higher cycle time variability. White matter hyperintensities weakened these associations. Lower myelin in specific white matter tracts may contribute to higher gait variability, increasing the overall risk of mobility impairment.
KW - cerebrovascular disease
KW - functional decline
KW - Mobility
KW - white matter lesion
UR - https://www.scopus.com/pages/publications/85135905669
U2 - 10.1016/j.neurobiolaging.2022.03.020
DO - 10.1016/j.neurobiolaging.2022.03.020
M3 - Journal article
C2 - 35973379
AN - SCOPUS:85135905669
SN - 0197-4580
VL - 119
SP - 56
EP - 66
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -