@article{7bbc0826f1734ca2ad6e062e39db58e4,
title = "Multimodal Visualization of Bioorthogonal Systems by Off–On Luminescence and Enhanced Magnetic Resonance Imaging",
abstract = "Bioorthogonal chemistry is a rising field investigating chemical reactions in physiological environments with high specificity. However, only very few examples concern the real-time monitoring of bioorthogonal reactions by luminescence or magnetic relaxivity. To fill this gap, herein, the Eu(III)-based complex is reported as a small-molecule optical imaging agent which shows off–on luminescence and provides quantitative analysis for the progress of the bioorthogonal reaction. The characteristic signal is achieved through efficient energy harvesting and transferring to the Eu(III) from the expansion of the conjugated system of the antenna. Moreover, the gadolinium(III) counterpart significantly enhances relaxivity in magnetic resonance imaging (MRI) after the bioorthogonal reaction since the rotational correlation time is shortened with increased molecular sizes and weights.",
keywords = "bioorthogonal chemistry, lanthanides, luminescence, magnetic resonance imaging",
author = "Chen Xie and Yue Wu and Chau, {Ho Fai} and Tao Zhang and Wong, {Carlos Tinlong} and Yeung, {Yik Hoi} and Lam, {Pak Lun} and B{\"u}nzli, {Jean Claude G.} and Charbonni{\`e}re, {Lo{\"i}c J.} and Law, {Ga Lai} and Wong, {Ka Leung}",
note = "Funding Information: C.X. and Y.W. contributed equally to this work. G.-L.L. gratefully acknowledges The Hong Kong Polytechnic University ((a) University Research Facility in Chemical and Environmental Analysis (UCEA); (b) University Research Facility in Life Sciences (ULS)) and the Hong Kong Research (grant Nos. 15300919, 15301120, and 153021/18P). K.-L.W. gratefully acknowledges the financial assistance from the Hong Kong Research Grants Council (grant No. 12300021), Dr. Mok Man Hung Endowed Professorship in Chemistry, HKBU–Durham Lanthanide Joint Research Center – Lanthanide Tools for Systems Medicine (grant No. SDF19-1011-P02), and the Centre for Medical Engineering of Molecular and Biological Probes (grant No. AoE/M-401/20). Funding Information: C.X. and Y.W. contributed equally to this work. G.‐L.L. gratefully acknowledges The Hong Kong Polytechnic University ((a) University Research Facility in Chemical and Environmental Analysis (UCEA); (b) University Research Facility in Life Sciences (ULS)) and the Hong Kong Research (grant Nos. 15300919, 15301120, and 153021/18P). K.‐L.W. gratefully acknowledges the financial assistance from the Hong Kong Research Grants Council (grant No. 12300021), Dr. Mok Man Hung Endowed Professorship in Chemistry, HKBU–Durham Lanthanide Joint Research Center – Lanthanide Tools for Systems Medicine (grant No. SDF19‐1011‐P02), and the Centre for Medical Engineering of Molecular and Biological Probes (grant No. AoE/M‐401/20). Publisher Copyright: {\textcopyright} 2023 The Authors. Advanced Optical Materials published by Wiley-VCH GmbH.",
year = "2023",
month = jun,
day = "5",
doi = "10.1002/adom.202203057",
language = "English",
volume = "11",
journal = "Advanced Optical Materials",
issn = "2195-1071",
publisher = "John Wiley and Sons Inc.",
number = "11",
}