TY - JOUR
T1 - Multifunctional layered black phosphorene-based nanoplatform for disease diagnosis and treatment: a review
AU - Huang, Xiazi
AU - Zhou, Yingying
AU - Woo, Chi Man
AU - Pan, Yue
AU - Nie, Liming
AU - Lai, Puxiang
N1 - Funding Information:
Liming Nie earned his Ph.D. degree in Optics from South China Normal University, China. He received his postdoctoral training under Dr. Lihong V. Wang at Washington University in St. Louis, USA, from 2010 to 2012. Thereafter, he worked on molecular imaging as a research associate at National Institute of Health, USA. In 2014, he joined Xiamen University, China, as a faculty member and was promoted to full professor in 2018. His laboratory is transitioning to the Guangdong Academy of Medical Sciences, China. He edited and co-authored two textbooks on molecular imaging. His laboratory focuses on optical molecular imaging technology advancement and applications, mainly on photoacoustic microscopy, functional photoacoustic tomography, and other imaging modalities, such as magnetic resonance imaging and positron emission tomography. He has published over 70 peer-reviewed articles in several journals, including Nature Communications, Angewandte Chemie International Edition, European Radiology, and The Journal of Nuclear Medicine, and has delivered more than 30 plenary speeches or invited talks in international conferences. His work has been cited by Nature Method, Neuron, PNAS, etc. His Google Scholar H-index and citations have reached 34 and 4300, respectively. He has received numerous research funding awards from the National Natural Science Foundation of China as well as the Ministry of Science and Technology of China. He received the ACS Young Scientist Award and the first-place award of Huaxia Medical Technology.
Funding Information:
Dr. Lai’s research focuses on the synergy of light and sound as well as their applications in biomedicine, such as wavefront shaping, photoacoustic imaging, acousto-optic imaging, and computational optical imaging. His research has fueled more than 50 publications in top journals, such as Nature Photonics, Nature Communications, and Advanced Sciences. Since 2015, his research has been continuously supported by the National Natural Science Foundation of China (NSFC), Hong Kong Research Grant Council (RGC), Hong Kong Innovation and Technology Commission (ITC), Department of Science and Technology of Guangdong Province, and Shenzhen Science and Technology Innovation Commission (STIC), with an allocated budget of more than 19 million Hong Kong dollars.
Funding Information:
Dr. Lai was awarded the 2016–2017 Hong Kong RGC Early Career Award, 2018 Hong Kong Polytechnic University Faculty of Engineering Research Grant Achievement Award, 2019 PolyU K.C. Wong Belt and Road Visiting Fellowship Award, and 2020 Hong Kong Polytechnic University Faculty of Engineering Faculty Research Award. In recognition of his contribution to the field, currently, Puxiang serves as an Associate Editor of Journal of Visual Computing for Industry, Biomedicine, and Art (VCIBA); a Guest Editor of Journal of Innovative Optics in Health and Science (JIOHS); a Committee Member of the Biomedical Optics Panel in the Chinese Society of Biomedical Engineering; and a Member of the Medical Instrument Judging Panel in the Shenzhen Science and Technology Innovation Commission. Acknowledgements
Funding Information:
This work was supported in part by the National Natural Science Foundation of China (NSFC) (Grant Nos. 81930048, 81627805, and 81671726), Guangdong Science and Technology Commission (Nos. 2019BT02X105, 2019A1515011374), Hong Kong Research Grant Council (Nos. 25204416, R5029-19), Hong Kong Innovation and Technology Commission (Nos. ITS/022/18, GHP/043/19SZ, GHP/044/19GD), Shenzhen Science and Technology Innovation Commission (No. JCYJ20170818104421564), Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars (No. 2020B1515020027), and Guangzhou Science and Technology Bureau (No. 202002020070).
Publisher Copyright:
© 2020, Higher Education Press.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/26
Y1 - 2020/11/26
N2 - As an outstanding two-dimensional material, black phosphorene, has attracted significant attention in the biomedicine field due to its large surface area, strong optical absorption, distinct bioactivity, excellent biocompatibility, and high biodegradability. In this review, the preparation and properties of black phosphorene are summarized first. Thereafter, black phosphorene-based multifunctional platforms employed for the diagnosis and treatment of diseases, including cancer, bone injuries, brain diseases, progressive oxidative diseases, and kidney injury, are reviewed in detail. This review provides a better understanding of the exciting properties of black phosphorene, such as its high drug-loading efficiency, photothermal conversion capability, high 1O2 generation efficiency, and high electrical conductivity, as well as how these properties can be exploited in biomedicine. Finally, the research perspectives of black phosphorene are discussed.[Figure not available: see fulltext.]
AB - As an outstanding two-dimensional material, black phosphorene, has attracted significant attention in the biomedicine field due to its large surface area, strong optical absorption, distinct bioactivity, excellent biocompatibility, and high biodegradability. In this review, the preparation and properties of black phosphorene are summarized first. Thereafter, black phosphorene-based multifunctional platforms employed for the diagnosis and treatment of diseases, including cancer, bone injuries, brain diseases, progressive oxidative diseases, and kidney injury, are reviewed in detail. This review provides a better understanding of the exciting properties of black phosphorene, such as its high drug-loading efficiency, photothermal conversion capability, high 1O2 generation efficiency, and high electrical conductivity, as well as how these properties can be exploited in biomedicine. Finally, the research perspectives of black phosphorene are discussed.[Figure not available: see fulltext.]
KW - bioimaging
KW - black phosphorus (BP)
KW - bone regeneration
KW - cancer therapy
KW - delivery nanoplatform
UR - http://www.scopus.com/inward/record.url?scp=85096550279&partnerID=8YFLogxK
U2 - 10.1007/s12200-020-1084-1
DO - 10.1007/s12200-020-1084-1
M3 - Review article
AN - SCOPUS:85096550279
SN - 2095-2759
VL - 13
SP - 327
EP - 351
JO - Frontiers of Optoelectronics
JF - Frontiers of Optoelectronics
IS - 4
ER -
