M2+Doping Induced Simultaneous Phase/Size Control and Remarkable Enhanced Upconversion Luminescence of NaLnF4Probes for Optical-Guided Tiny Tumor Diagnosis

Youbin Li, Xiaolong Li, Zhenluan Xue, Mingyang Jiang, Songjun Zeng, Jianhua Hao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

24 Citations (Scopus)


KGaA, Weinheim Doping has played a vital role in constructing desirable hybrid materials with tunable functions and properties via incorporating atoms into host matrix. Herein, a simple strategy for simultaneously modifying the phase, size, and upconversion luminescence (UCL) properties of the NaLnF4(Ln = Y, Yb) nanocrystals by high-temperature coprecipitation through nonequivalent M2+doping (M = Mg2+, Co2+) has been demonstrated. The phase transformation from cubic to hexagonal is readily achieved by doping M2+. Compared with Mg-free sample, a remarkable enhancement of overall UCL (≈27.5 times) is obtained by doping Mg2+. Interestingly, owing to the efficient UCL, red UCL-guided tiny tumor (down to 3 mm) diagnosis is demonstrated for the first time. The results open up a new way of designing high efficient UCL probe with combination of hexagonal phase and small size for tiny tumor detection.
Original languageEnglish
Article number1601231
JournalAdvanced healthcare materials
Issue number10
Publication statusPublished - 24 May 2017


  • cubic to hexagonal phase transformation
  • M doping 2+
  • optical-guided tiny tumor diagnosis
  • phase/size control

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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