@article{8d6f04f88d1e440bb3fcdd7e7446df96,
title = "Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness",
abstract = "Asthma, accompanied by lung inflammation, bronchoconstriction and airway hyper-responsiveness, is a significant public health burden. Here we report that Mas-related G protein-coupled receptors (Mrgprs) are expressed in a subset of vagal sensory neurons innervating the airway and mediates cholinergic bronchoconstriction and airway hyper-responsiveness. These findings provide insights into the neural mechanisms underlying the pathogenesis of asthma.",
author = "Liang Han and Nathachit Limjunyawong and Fei Ru and Zhe Li and Hall, \{Olivia J.\} and Haley Steele and Yuyan Zhu and Julie Wilson and Wayne Mitzner and Marian Kollarik and Undem, \{Bradley J.\} and Canning, \{Brendan J.\} and Xinzhong Dong",
note = "Funding Information: We thank M. Anderson at Johns Hopkins University Pain Imaging Core for assisting with ex vivo vagal GCaMP imaging. We thank S. Klein at Johns Hopkins University Department of Molecular Microbiology and Immunology for providing the mouse-adapted influenza A/California/04/2009 H1N1 virus. We thank R. Rabold and L. Zhen for providing technical support for Flexivent experiments. This study was supported by grants from the NIH (NS054791 to X.D., NS087088 to L.H., HL010342 to W.M., HL112919 to B.U., DK110366 to M.K. and HL122228 to B.C.) and by the American Asthma Foundation (to X.D.). Publisher Copyright: {\textcopyright} 2018 The Author(s). Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2018",
month = mar,
day = "1",
doi = "10.1038/s41593-018-0074-8",
language = "English",
volume = "21",
pages = "324--328",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Research",
number = "3",
}
